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A 32-kD GTP-Binding Protein Associated with the CD4-p56 lck and CD8-p56 lck T Cell Receptor Complexes
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The guanosine triphosphate (GTP)-binding proteins include signal-transducing heterotrimeric G proteins (for example, G
s
, G
i
), smaller GTP-binding proteins that function in protein sorting, and the oncogenic protein p21
ras
. The T cell receptor complexes CD4-p56
lck
and CD8-p56
lck
were found to include a 32- to 33-kilodalton phosphoprotein (p32) that was recognized by an antiserum to a consensus GTP-binding region in G proteins. Immunoprecipitated CD4 and CD8 complexes bound GTP and hydrolyzed it to guanosine diphosphate (GDP). The p32 protein was covalently linked to [α-
32
P]GTP by ultraviolet photoaffinity labeling. These results demonstrate an interaction between T cell receptor complexes and an intracellular GTP-binding protein.
American Association for the Advancement of Science (AAAS)
Title: A 32-kD GTP-Binding Protein Associated with the CD4-p56
lck
and CD8-p56
lck
T Cell Receptor Complexes
Description:
The guanosine triphosphate (GTP)-binding proteins include signal-transducing heterotrimeric G proteins (for example, G
s
, G
i
), smaller GTP-binding proteins that function in protein sorting, and the oncogenic protein p21
ras
.
The T cell receptor complexes CD4-p56
lck
and CD8-p56
lck
were found to include a 32- to 33-kilodalton phosphoprotein (p32) that was recognized by an antiserum to a consensus GTP-binding region in G proteins.
Immunoprecipitated CD4 and CD8 complexes bound GTP and hydrolyzed it to guanosine diphosphate (GDP).
The p32 protein was covalently linked to [α-
32
P]GTP by ultraviolet photoaffinity labeling.
These results demonstrate an interaction between T cell receptor complexes and an intracellular GTP-binding protein.
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