In-vivo and Histopathological Evaluation of Antidiabetic activity of Combination Extract of Garcinia indica and Lannea coromandelica in STZ-NA induced in Rats

In order to manage type-II diabetes mellitus, the current study assesses the antidiabetic potential of a polyherbal extract made of Lannea Coromandelica(Indian Ash Plant) and Garcinia Indica (Kokum). Although earlier studies have demonstrated the effectiveness of these herbs alone in the treatment of diabetes, this study concentrated on their combined effects. Streptozotocin-induced diabetic Wistar rats were given different quantities of the polyherbal extract, and the results were compared to a group that received normal antidiabetic medication treatment. According to the results, the polyherbal combination considerably lowered blood glucose levels and lessened the negative symptoms of hyperglycemia. Additionally, rats treated with the polyherbal extract displayed a considerable improvement in body weight, suggesting its potential to ameliorate diabetes-related weight loss. The bioactive substances in these herbal extracts worked together to improve overall physiological function and improve glycemic management. In addition to highlighting the advantages of polyherbal formulations as an alternative to traditional treatment, this study reveals the synergistic therapeutic effects of Lannea Coromandelica and Garcinia Indica in the management of diabetes.