Angiotensinogen - A Potential Diagnostic and Prognostic Candidate Gene  for Adenocarcinomas of Rectum and Stomach

<p>The Angiotensinogen (AGT) gene encodes for angiotensinogen protein that mainly regulates blood pressure and maintains the fluid and salt balance in the body. AGT expression variations have been documented earlier in only a few subtypes of human cancers, the multi-omics profiling of AGT as a shared biomarker in different other subtypes of human cancers remains to be uncovered. In the current study, AGT multi-omics analysis in 24 major subtypes of human cancer were performed using different authentic online databases and bioinformatics analysis including UALCAN, Kaplan Meier (KM) plotter, Human protein Atlas (HPA), GENT2, MEXPRESS, cBioportal, STRING, DAVID, TIMER., and CTD database. AGT is found commonly up-regulated in most human cancers. Overexpression of AGT is significantly correlated with the poor overall survival (OS) of only rectum adenocarcinoma (READ) and Stomach Adenocarcinoma (STAD). This implies that AGT plays a significant role in the development and progression of these cancers. We further noticed that AGT is also overexpressed in READ and STAD patients of different clinicopathological features. Pathways enrichment analysis revealed that AGT is involved in various diverse pathways. While, a few interesting correlations were also documented between AGT expression and its promoter methylation level, CD8+ T immune cells level, and CNVs. Moreover, we also predicted a few drugs through gene-drug interaction analysis that could be used in the treatment of READ and STAD by regulating the AGT expression. Our findings suggest that AGT alone might be helpful in predicting the diagnosis and prognosis of READ and STAD patients commonly.</p>