Impairment of Liver Function in Pre-Eclamptic Patients in North East Medical College Hospital

Abstract This study was conducted to see the change of liver function in preeclampsia in comparison to normal pregnancy. This cross-sectional comparative study was conducted in the Department of Obstetrics and Gynaecology, North East Medical College Hospital, Sylhet during the period from September 2015 to February 2016. Fifty one diagnosed cases of preeclampsia and 51 uncomplicated normal pregnancies fulfilling the inclusion and exclusion criteria were selected. Serum bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were estimated. There was no significant age difference between the preeclampsia group [25.27 (SD 4.74) years] and normal pregnancy group 25.04 (SD 4.21) years) (p=0.792). Serum bilirubin level was 1.01 (SD 0.17) mg/dl in pre-eclamptic women and 0.73 (SD 0.14) mg/dl in normal pregnant women; significantly higher in pre-eclamptic women compared to normal pregnant women (p<0.001). Serum ALT level was 43.86 (SD 10.47) U/L in pre-eclamptic women and 27.25 (SD 9.53) U/L in normal pregnant women; significantly higher in pre-eclamptic women compared to normal pregnant women (p<0.001). Serum AST level was 49.84 (SD 13.22) U/L in pre-eclamptic women and 24.67 (SD 11.76) U/L in normal pregnant women; significantly higher in pre-eclamptic women compared to normal pregnant women (p<0.001). Serum ALP level was 253.63 (SD 11.54) U/L in pre-eclamptic women and 242 (SD 8.15) U/L in normal pregnant women; significantly higher in pre-eclamptic women compared to normal pregnant women (p<0.001). Serum bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase was impaired in pre-eclampsia compare to normal pregnancy. Key Words: Impairment, Liver Function, Pre-eclampsia.