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Formulation and Evaluation of Fast Disintigrating Meloxicam Tablets and Its Comparison with Marketed Product
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The present investigation deals with the formulation of fast disintegrating tablets of Meloxicam that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Meloxicam is a newer selective COX-1 inhibitor. The tablets were prepared by wet granulation procedure. The influence of superdisintegrants, crosspovidone, croscaremellose sodium on disintegration time, wetting time and water absorption ratio were studied. Tablets were evaluated for weight and thickness variation, disintegration time, drug content, in vitro dissolution, wetting time and water absorption ratio. The in vitro disintegration time of the best fast disintegrating tablets was found to be 18 sec. Tablets containing crospovidone exhibit quick disintegration time than tablets containing croscaremellose sodium. The fast disintegrating tablets of Meloxicam with shorter disintegration time, acceptable taste and sufficient hardness could be prepared using crospovidone and other excipients at optimum concentration.
Dr. Yashwant Research Labs Pvt. Ltd.
Title: Formulation and Evaluation of Fast Disintigrating Meloxicam Tablets and Its Comparison with Marketed Product
Description:
The present investigation deals with the formulation of fast disintegrating tablets of Meloxicam that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy.
Meloxicam is a newer selective COX-1 inhibitor.
The tablets were prepared by wet granulation procedure.
The influence of superdisintegrants, crosspovidone, croscaremellose sodium on disintegration time, wetting time and water absorption ratio were studied.
Tablets were evaluated for weight and thickness variation, disintegration time, drug content, in vitro dissolution, wetting time and water absorption ratio.
The in vitro disintegration time of the best fast disintegrating tablets was found to be 18 sec.
Tablets containing crospovidone exhibit quick disintegration time than tablets containing croscaremellose sodium.
The fast disintegrating tablets of Meloxicam with shorter disintegration time, acceptable taste and sufficient hardness could be prepared using crospovidone and other excipients at optimum concentration.
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