Salmonella Infection and Pathogenesis

Salmonella genus represents most common food borne pathogens isolated from food producing animals and is responsible for causing zoonotic infections in humans and other animal species, including birds. As a result, Salmonella diseases are among the most common problems for the humans, animals, and food industry around the world. Despite rising attention about other pathogens, Salmonella continues to be the most prominent cause of food borne disease worldwide. Salmonella can be transferred to humans at any point along the farm-to-fork chain, most commonly through infected animal-derived foods such as poultry and poultry related products (eggs), pork, fish, and so on. Some Salmonella serotypes have been confined to a single serovar and are known as “host-restricted” while the others have a wide host spectral range and are known as “host-adapted” serotypes. Globally Salmonella infection causes huge mortality and the infection plays a huge role in immune response by evolving multiple mechanism to subvert immunity to its own benefit. Numerous infectivity markers and determinants have indeed been reported to play essential role in Salmonella pathogenesis to colonize its host by invading and avoiding the host’s intestinal shielding system.