Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Identification of BAP1-associated MicroRNAs and Implications in Cancer Development
View through CrossRef
Having role in gene regulation and silencing, miRNAs have been implicated in development and
progression of a number of diseases, including cancer. Herein, I present potential miRNAs associated with
BAP1 gene identified using in-silico tools such as TargetScan and Exiqon miRNA Target Prediction. I
identified fifteen highly conserved miRNA (hsa-miR-423-5p, hsa-miR-3184-5p, hsa-miR-4319, hsa-miR125b-5p, hsa-miR-125a-5p, hsa-miR-6893-3p, hsa-miR-200b-3p, hsa-miR-200c-3p, hsa-miR-505-3p.1,
hsa-miR-429, hsa-miR-370-3p, hsa-miR-125a-5p, hsa-miR-141-3p, hsa-miR-200a-3p, and hsa-miR-429)
associated with BAP1 gene. We also predicted the differential regulation of these twelve miRNAs in
different cancer types.
Science Repository OU
Title: Identification of BAP1-associated MicroRNAs and Implications in Cancer Development
Description:
Having role in gene regulation and silencing, miRNAs have been implicated in development and
progression of a number of diseases, including cancer.
Herein, I present potential miRNAs associated with
BAP1 gene identified using in-silico tools such as TargetScan and Exiqon miRNA Target Prediction.
I
identified fifteen highly conserved miRNA (hsa-miR-423-5p, hsa-miR-3184-5p, hsa-miR-4319, hsa-miR125b-5p, hsa-miR-125a-5p, hsa-miR-6893-3p, hsa-miR-200b-3p, hsa-miR-200c-3p, hsa-miR-505-3p.
1,
hsa-miR-429, hsa-miR-370-3p, hsa-miR-125a-5p, hsa-miR-141-3p, hsa-miR-200a-3p, and hsa-miR-429)
associated with BAP1 gene.
We also predicted the differential regulation of these twelve miRNAs in
different cancer types.
Related Results
Abstract 1757: Spectrum of BAP1 mutations identified in diverse cancer lineages
Abstract 1757: Spectrum of BAP1 mutations identified in diverse cancer lineages
Abstract
Background: Germline mutations in the tumor suppressor gene, BAP1, a deubiquitylase that regulates key cellular pathways, are associated with a recently-des...
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress
Uveal melanoma (UM) is the deadliest form of eye cancer in adults. Inactivating mutations and/or loss of expression of the gene encoding BRCA1-associated protein 1 (BAP1) in UM tum...
A mechanistic study of the Polycomb PR-DUB complex
A mechanistic study of the Polycomb PR-DUB complex
Etude du complexe Polycomb PR-DUB : une approche mécanistique
BAP1 est un suppresseur de tumeurs dont le nombre de partenaires protéiques rend complexe l'appréhensi...
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Abstract
A cervical rib (CR), also known as a supernumerary or extra rib, is an additional rib that forms above the first rib, resulting from the overgrowth of the transverse proce...
Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in
BAP1
mut
uveal melanoma
Transcriptional regulators FOXD1 and RBFOX2 contribute to metastatic capacity in
BAP1
mut
uveal melanoma
Abstract
Uveal melanoma is the most prevalent primary intraocular cancer, with a significant metastatic risk. This risk is dependent on the genet...
BAP1 serves as a clear-cell renal cell carcinoma suppressor and is inversely regulated by miR-200c-3p
BAP1 serves as a clear-cell renal cell carcinoma suppressor and is inversely regulated by miR-200c-3p
Abstract
The initiation and development of malignant tumor is always accompanied by a series of complex gene expression alterations inside the cells. As a tumor suppressor,...
Abstract 3171: Hyperactive MAPK dysregulation of microRNAs contributes to the ER-negative phenotype in breast cancer
Abstract 3171: Hyperactive MAPK dysregulation of microRNAs contributes to the ER-negative phenotype in breast cancer
Abstract
We have previously shown that hyperactive MAPK (hMAPK) signaling in breast cancer results in repression of estrogen receptor (ER) expression and regulates g...
BAP1/ASXL1 recruitment and activation for H2A deubiquitination
BAP1/ASXL1 recruitment and activation for H2A deubiquitination
Abstract
The deubiquitinating enzyme BAP1 is an important tumor suppressor that has drawn attention in the clinic since its loss leads to a variety of cancers. BA...