Effect of Antioxidant Activity of Red Dragon Fruit (Hylocereus polyrhizus) Peel on Fibroblast Proliferation in the Healing Process of Oral Ulcers in Wistar Rats

The purpose of this study is to understand effect of antioxidant activity of red dragon fruit (Hylocereus polyrhizus) peel on fibroblast proliferation in the healing process of oral ulcers in wistar rats. This type of research is a quasi-laboratory experiment with a randomized post test only control group design. This research will be carried out from May to June 2022, including the preparation of red dragon fruit (Hylocereus polyrhizus) peel extract, antioxidant activity tests, making wounds until the time for wound healing, as well as histopathological examination. The population of are wistar rats bred at Eldwin Laboratory is 300 individuals. Based on the calculation, the total sample in this study is 10 multiplied by 3 so there are 30 samples. The data obtained is not normally distributed then the statistical test is continued with kruskal-willis test to determine differences in the effectiveness of red dragon fruit (Hylocereus polyrhizus) peel extract in all groups. The results show that there is an effect of antioxidant activity of red dragon fruit (Hylocereus polyrhizus) peel extract on fibroblast proliferation in the healing process of oral ulcers in wistar rats. Keywords: Antioxidant Activity, Red Dragon Fruit, Peel, Fibroblast Proliferation