Anti-hypercholesterol effects of microencapsulation of leaf extract Stevia rebaudiana

Several studies have proven that Stevia rebaudiana Bertoni leaf extract has been shown to be able to lower cholesterol. Furthermore, microencapsulation was developed to protect the content in the plant. This study aims to determine the effect of microencapsulated preparations of leaf extract of Stevia rebaudiana Bertoni on cholesterol in male Wistar rats. The encapsulants used are inulin and chitosan. This study was conducted with the aim of making hypercholesterol rats induced by alloxan at a dose of 150 mg/KgBW rats intraperitoneally. Hypercholesterolemic rats were given microencapsulated Stevia rebaudiana Bertoni leaf extract at different dose levels (100, 300, 700 and 1000 mg/kgBW) for 8 weeks; control mice were fed a basal diet during this period. The results of the study concluded that the microencapsulation of the leaf extract of Stevia rebaudiana Bertoni had an antihypercholesterolemic effect on male Wistar strain rats.