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EFFICIENT SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(3-ARYL-4,5-DIHYDRO-1H-PYRAZOL-5-YL)-2- (TRIFLUOROMETHYL)-1,8-NAPHTHYRIDINES
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An efficient synthesis of 3-(3-Aryl-4,5-dihydro-1H-pyrazol-5-yl)-2-(trifluoromethyl)-1,8-naphthyridines 5(a-h) was achieved by the cyclo condensation of 1-Aryl-3-(2-(trifluoromethyl)-1,8-naphthyridin-3-yl)prop-2-en-1-ones(4a-h) with hydrazine hydrate. The compounds 4(a-h) were synthesized through a three-step procedure starting from ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate (1). Antibacterial and antifungal activities of the final compounds 5(a-h) have been screened and compound 5h exhibited significant inhibition of bacterial and fungal growth. The structures of compounds 3-5 are assigned on the basis of their elemental analysis and spectral (IR, 1H NMR, and MS) data.
Rasayan Journal of Chemistry
Title: EFFICIENT SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-(3-ARYL-4,5-DIHYDRO-1H-PYRAZOL-5-YL)-2- (TRIFLUOROMETHYL)-1,8-NAPHTHYRIDINES
Description:
An efficient synthesis of 3-(3-Aryl-4,5-dihydro-1H-pyrazol-5-yl)-2-(trifluoromethyl)-1,8-naphthyridines 5(a-h) was achieved by the cyclo condensation of 1-Aryl-3-(2-(trifluoromethyl)-1,8-naphthyridin-3-yl)prop-2-en-1-ones(4a-h) with hydrazine hydrate.
The compounds 4(a-h) were synthesized through a three-step procedure starting from ethyl 2-(trifluoromethyl)-1,8-naphthyridine-3-carboxylate (1).
Antibacterial and antifungal activities of the final compounds 5(a-h) have been screened and compound 5h exhibited significant inhibition of bacterial and fungal growth.
The structures of compounds 3-5 are assigned on the basis of their elemental analysis and spectral (IR, 1H NMR, and MS) data.
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