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Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic‐polycytidylic acid (POLY I:C) and interferon
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AbstractPoly I:C (polyinosinic‐polycytidylic acid) stimulated hyaluronic acid production by rheumatoid and non‐rheumatoid human synovial fibroblasts. Stimulation was dose dependent and was inhibited by acetylsalicylic acid and indomethacin. Poly I and Poly C, when separately added, had no stimulatory effect on hyaluronic acid production, and Poly A:U had only a slight effect on this parameter. Cells grown with Poly I:C were virus resistant and interferon was detected in their medium. Human interferon had also a dose‐dependent stimulatroy effect on hyaluronic acid production by synovial cells. A possible interferon‐mediated relationship between virus infection and pathologic accumulation of joint fluid is suggested.
Title: Hyaluronic acid produced by human synovial fibroblasts. Effect of polyinosinic‐polycytidylic acid (POLY I:C) and interferon
Description:
AbstractPoly I:C (polyinosinic‐polycytidylic acid) stimulated hyaluronic acid production by rheumatoid and non‐rheumatoid human synovial fibroblasts.
Stimulation was dose dependent and was inhibited by acetylsalicylic acid and indomethacin.
Poly I and Poly C, when separately added, had no stimulatory effect on hyaluronic acid production, and Poly A:U had only a slight effect on this parameter.
Cells grown with Poly I:C were virus resistant and interferon was detected in their medium.
Human interferon had also a dose‐dependent stimulatroy effect on hyaluronic acid production by synovial cells.
A possible interferon‐mediated relationship between virus infection and pathologic accumulation of joint fluid is suggested.
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