Chronic toxicity study of Somanathi Tamra Bhasma in albino- rats

Somanathi Tamra Bhasma, a special method of Tamra bhasma preparation, was studied for its chronic toxicity in Wistar strain albino rats. In this study Somanathi Tamra Bhasma was administered orally daily to different groups of albino rats in TED (Therapeutically effective dose), TED×5 (5 times the therapeutically effective dose) and TED×10 (10 times the therapeutically effective dose) doses for 3 months by following Ayush guidelines for evaluation of ASU drugs. Behavioural, ponderal, hematological, biochemical and histopathological parameters were considered for the assessment of data. Somanathi Tamra Bhasma was found to be relatively safe at TED and TED×5 dose levels when behavioural, ponderal, hematological, bio-chemical and histopathological parameters were studied and mild to moderate toxic at TED×10 treated group. The overall chronic toxicity study data indicates that the test substance Somanathi Tamra Bhasma at TED and TED×5 dose levels is very well tolerated since no toxicity symptoms were observed in these groups in any of the parameters analyzed.