Improvement of Aqueous solubility of Poorly Water-Soluble Drug (Ibuprofen) Using Mixed Solvency Technique

The efficacy of the drug is mainly dependent on dissolution and bioavailability. With many drugs available today showing poor aqueous, solubility becomes a major challenge for dosage formulation in the pharmaceutical industry. It is estimated that 40% of active new chemical entities identified in combinatorial screening programs are poorly water-soluble. Solubility enhancement processes are widely employed by the pharmaceutical industry to improve the dissolution as well as the bioavailability of poorly water-soluble drugs. The research survey suggests that more than 90% of drugs are orally administered. The therapeutic effectiveness of a drug depends mainly upon the bioavailability and ultimately upon the solubility of drug molecules. Many important drug characteristics like absorption, bioavailability, and pharmacokinetic profile of orally administered drug substances are highly dependent on the solubility of that compound in aqueous medium. Solubility is one of the important parameters to achieve the desired concentration of drug in systemic circulation for pharmacological response to be shown. Currently, only 8% of new drug candidates come under BCS class Idrugs. Every year more than 40%of drug candidates fail to reach the market due to poor aqueous solubility. Hydrotropy is a novel solubilization technique in which hydrotropes are utilized to increase the aqueous solubility of poorly aqueous soluble drugs. Hydrotropy does not involve the use of harmful organic chemicals and is economical compared to other solubilization techniques.