Ataxia in Multiple Sclerosis: From Current Understanding to Therapy

Ataxia is a type of neurological disorder that affects the ability to coordinate voluntary movements, such as walking, balance, and speech. In people with multiple sclerosis (MS), ataxia is a common symptom, affecting around 80% of people with the condition. The cause of ataxia in MS is still unknown; however, it is thought to be due to damage to the part of the central nervous system (CNS) that controls balance, coordination, and movement, especially the cerebellum. Symptoms of ataxia in people with MS can range from mild to severe, and can include a lack of coordination, difficulty speaking, difficulty walking, and gait. Ataxia management in MS typically involves pharmacotherapy to improve coordination, physiotherapy to enhance strength and balance, surgical procedures to alleviate tremor as well as occupational therapy to help with everyday activities.