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Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain
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AbstractThe effects of benzophenanthridine alkaloids, such as sanguinarine and chelidonine, on monoamine oxidase (MAO) activity in mouse brain were investigated. Sanguinarine showed an inhibitory effect on MAO activity in a concentration dependent manner (53.4% inhibition at 25 µM). However, chelidonine did not inhibit MAO activity. The IC50 value of sanguinarine was 24.5 µM. Sanguinarine inhibited non‐competitively MAO activity using kynuramine as a substrate. The Ki value for sanguinarine was 22.1 µM. These results suggest that sanguinarine partially contributes to the regulation of catecholamine content. Copyright © 2001 John Wiley & Sons, Ltd.
Title: Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain
Description:
AbstractThe effects of benzophenanthridine alkaloids, such as sanguinarine and chelidonine, on monoamine oxidase (MAO) activity in mouse brain were investigated.
Sanguinarine showed an inhibitory effect on MAO activity in a concentration dependent manner (53.
4% inhibition at 25 µM).
However, chelidonine did not inhibit MAO activity.
The IC50 value of sanguinarine was 24.
5 µM.
Sanguinarine inhibited non‐competitively MAO activity using kynuramine as a substrate.
The Ki value for sanguinarine was 22.
1 µM.
These results suggest that sanguinarine partially contributes to the regulation of catecholamine content.
Copyright © 2001 John Wiley & Sons, Ltd.
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