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SCREENING ON XANTHINE OXIDASE INHIBITORY ACTIVITY OF SOME VIETNAM MEDICINAL PLANTS
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Background: Xanthine oxidase inhibitory activity was assayed from twelve species used for the treatment of gout and related activity such as antioxidant, anti-inflammatory and analgesic activity by indigenous people of Vietnam.
Materials and method: The leaves of these plants were extracted with methanol solvent and then to test the xanthine oxidase inhibitory activity in vitro through the modified Tadataka Noro’s spectrophotometric method.
Results: Of the 36 extracts assayed, 11 extracts demonstrated xanthine oxidase inhibitory activity at 100μg/ml, 8 extracts demonstrated xanthine oxidase inhibitory activity at 50μg/ml and 2 extracts demonstrated xanthine oxidase inhibitory activity at 10μg/ml. The methanol extracts of Bryophyllum pinnatum and Annona glabra showed an inhibition greater than 50%.
Conclusion: The methanol extracts of Bryophyllum pinnatum (Lam.) Kurz. (Crassulaceae) and Annona glabra L. (Annonaceae) presented xanthine oxidase inhibitory activity with IC50 values of 59.42 and 70.92μg/ml, respectively.
Key words: Vietnamese medicinal plants, Xanthine oxidase inhibitory activity, Gout
Hue University of Medicine and Pharmacy
Title: SCREENING ON XANTHINE OXIDASE INHIBITORY ACTIVITY OF SOME VIETNAM MEDICINAL PLANTS
Description:
Background: Xanthine oxidase inhibitory activity was assayed from twelve species used for the treatment of gout and related activity such as antioxidant, anti-inflammatory and analgesic activity by indigenous people of Vietnam.
Materials and method: The leaves of these plants were extracted with methanol solvent and then to test the xanthine oxidase inhibitory activity in vitro through the modified Tadataka Noro’s spectrophotometric method.
Results: Of the 36 extracts assayed, 11 extracts demonstrated xanthine oxidase inhibitory activity at 100μg/ml, 8 extracts demonstrated xanthine oxidase inhibitory activity at 50μg/ml and 2 extracts demonstrated xanthine oxidase inhibitory activity at 10μg/ml.
The methanol extracts of Bryophyllum pinnatum and Annona glabra showed an inhibition greater than 50%.
Conclusion: The methanol extracts of Bryophyllum pinnatum (Lam.
) Kurz.
(Crassulaceae) and Annona glabra L.
(Annonaceae) presented xanthine oxidase inhibitory activity with IC50 values of 59.
42 and 70.
92μg/ml, respectively.
Key words: Vietnamese medicinal plants, Xanthine oxidase inhibitory activity, Gout.
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