Global prevalence of hyperuricemia in adolescents from 2000 to 2019: A meta-analysis

Abstract Background: Studies of the prevalence of hyperuricemia in adolescents have been limited to specific areas and the global prevalence is unknown. This study was to determine the prevalence of hyperuricemia in adolescents worldwide. Methods: A comprehensive search was conducted to identify all relevant studies in multiple databases. A meta-analysis was performed to determine the prevalence of hyperuricemia in adolescents worldwide. Results: The meta-analysis included 13 articles. The pooled prevalence of hyperuricemia in adolescents was 14.4% (95% CI 9.2–19.5%). Publication bias was observed but the results did not change after a trim and fill test, indicating that the impact of this bias was likely insignificant. Conclusions: Hyperuricemia prevalence in adolescents is high and continues to increase. The prevalence varies with geography, gender, and time. Effective measures should be taken to prevent any further increase in the incidence of adolescent hyperuricemia. Keywords: prevalence, hyperuricemia, adolescents