ThP2.16 - A prospective study with meta-analysis of echocardiographic changes of left ventricular function in aortic valve replacement patients

Abstract   Aortic valve replacement (AVR) improves cardiac function and it reverses adverse remodeling. Measurements of left ventricular ejection fraction (LVEF) are used to identify the patients for pharmacological therapy or AVR. Systematic review identified the Echocardiographic indices followed by AVR. Second part of this study compares the Echocardiographic indices of the patients, who had followed AVR. Results Overall, 145 citations were identified from the initial search, of which 43 studies were retrieved. Later, 8 studies included in the review and 5 were subjected to meta-analysis. There was a change in peak A-wave (MD = 7.30; 95% CI = 5.51 to 9.09), peak E-wave (MD = 3.70; 95% CI = 1.86 to 5.54) before and after AVR. There was no change in LVEF (MD = 0.74; 95% CI = -0.76 to 2.25), E/A ratio (MD = -0.26; 95% CI = -0.75 to 0.23), diastolic dimension (MD = 1.10; 95% CI = -2.08 to 4.28) and systolic dimension (MD = 0.20; 95% CI = -3.41 to 3.81) among AVR cases. Prospective study includes 30 AVR cases. Of these, 23 (76.7%) males and 7 (23.3%) females with mean age was 63.36 + 8.34. There was a change (p >0.05) in peak E-wave, peak gradient and peak diastolic gradient from preoperative to six months after AVR. According to literature, peak E-wave, peak gradient, and peak diastolic gradient changed after AVR. E/A ratio, peak A-wave, E/E ratio, LVEF, diastolic dimension, and systolic dimension were stable (p >0.05) from preoperative to six months after AVR.