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Structure and Interactions of the Endogenous Human Commander Complex
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Abstract
The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle, and immune response. It consists of COMMD1-10, CCDC22, CCDC93, DENND10, and the Retriever sub-complex (VPS26C, VPS29, and VPS35L), all expressed ubiquitously in the body and linked to various diseases. Here, we report the structure and key interactions of the endogenous human Commander complex by cryogenic electron microscopy and mass spectrometry-based proteomics. The complex consists of a stable core of COMMD1–10 and an effector containing DENND10 and Retriever, scaffolded together by CCDC22 and CCDC93. We establish the composition of Commander and reveal major interaction interfaces. These findings clarify its roles in intracellular transport, and uncover a strong association with cilium assembly, and centrosome and centriole functions.
Springer Science and Business Media LLC
Title: Structure and Interactions of the Endogenous Human Commander Complex
Description:
Abstract
The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle, and immune response.
It consists of COMMD1-10, CCDC22, CCDC93, DENND10, and the Retriever sub-complex (VPS26C, VPS29, and VPS35L), all expressed ubiquitously in the body and linked to various diseases.
Here, we report the structure and key interactions of the endogenous human Commander complex by cryogenic electron microscopy and mass spectrometry-based proteomics.
The complex consists of a stable core of COMMD1–10 and an effector containing DENND10 and Retriever, scaffolded together by CCDC22 and CCDC93.
We establish the composition of Commander and reveal major interaction interfaces.
These findings clarify its roles in intracellular transport, and uncover a strong association with cilium assembly, and centrosome and centriole functions.
Related Results
Structure and Interactions of the Endogenous Human Commander Complex
Structure and Interactions of the Endogenous Human Commander Complex
Summary
The Commander complex, a 16-protein subunit assembly, plays multiple roles in various intracellular events, including regulation of cell homeostasis, cell c...
What are the Odds that Tetanus is an Endogenous Infection?
What are the Odds that Tetanus is an Endogenous Infection?
Tetanus is an infection caused by Clostridium tetani characterized by fever, cramped-up jaw, muscle spasms, headache, seizures, sweating, and trouble swallowing 3–21 days follo...
Crystallographic and spectroscopic assessment of pharmaceutical material mechanics
Crystallographic and spectroscopic assessment of pharmaceutical material mechanics
<p>Despite the advent of alternative dosage forms, solid dosage forms constitute a major proportion of dosage forms not only on the market, but also in many pharmaceutical co...
Commander Complex—A Multifaceted Operator in Intracellular Signaling and Cargo
Commander Complex—A Multifaceted Operator in Intracellular Signaling and Cargo
Commander complex is a 16-protein complex that plays multiple roles in various intracellular events in endosomal cargo and in the regulation of cell homeostasis, cell cycle and imm...
Recovery of seed-dispersal interactions and functions in tropical forest ecosystems
Recovery of seed-dispersal interactions and functions in tropical forest ecosystems
Biodiversity includes species and their interactions, which together are fundamental to maintaining ecosystem functioning. At the community level, species interactions form complex...
PERCEPTION OF THE COMMUNITY OF MUARA TEWEH CITY NORTH BARITO DISTRICT AGAINST THE STRUGGLE COMMANDER OF BATUR
PERCEPTION OF THE COMMUNITY OF MUARA TEWEH CITY NORTH BARITO DISTRICT AGAINST THE STRUGGLE COMMANDER OF BATUR
For heroic values to be well embedded in people's lives, good knowledge is also needed regarding the history of the struggle carried out by Commander Batur against Dutch colonial...
Endogenous amino acid flow in the avian ileum: quantification using three techniques
Endogenous amino acid flow in the avian ileum: quantification using three techniques
The aim of the present study was to compare the protein-free diet, guanidinated casein (GuC) and enzyme hydrolysed casein (EHC) methods for the quantification of endogenous amino a...
Brain Organoids, the Path Forward?
Brain Organoids, the Path Forward?
Photo by Maxim Berg on Unsplash
INTRODUCTION
The brain is one of the most foundational parts of being human, and we are still learning about what makes humans unique. Advancements ...