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Structure and Interactions of the Endogenous Human Commander Complex
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Abstract
The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle, and immune response. It consists of COMMD1-10, CCDC22, CCDC93, DENND10, and the Retriever sub-complex (VPS26C, VPS29, and VPS35L), all expressed ubiquitously in the body and linked to various diseases. Here, we report the structure and key interactions of the endogenous human Commander complex by cryogenic electron microscopy and mass spectrometry-based proteomics. The complex consists of a stable core of COMMD1–10 and an effector containing DENND10 and Retriever, scaffolded together by CCDC22 and CCDC93. We establish the composition of Commander and reveal major interaction interfaces. These findings clarify its roles in intracellular transport, and uncover a strong association with cilium assembly, and centrosome and centriole functions.
Springer Science and Business Media LLC
Title: Structure and Interactions of the Endogenous Human Commander Complex
Description:
Abstract
The Commander complex, a 16-protein assembly, plays multiple roles in cell homeostasis, cell cycle, and immune response.
It consists of COMMD1-10, CCDC22, CCDC93, DENND10, and the Retriever sub-complex (VPS26C, VPS29, and VPS35L), all expressed ubiquitously in the body and linked to various diseases.
Here, we report the structure and key interactions of the endogenous human Commander complex by cryogenic electron microscopy and mass spectrometry-based proteomics.
The complex consists of a stable core of COMMD1–10 and an effector containing DENND10 and Retriever, scaffolded together by CCDC22 and CCDC93.
We establish the composition of Commander and reveal major interaction interfaces.
These findings clarify its roles in intracellular transport, and uncover a strong association with cilium assembly, and centrosome and centriole functions.
Related Results
Structure and Interactions of the Endogenous Human Commander Complex
Structure and Interactions of the Endogenous Human Commander Complex
Summary
The Commander complex, a 16-protein subunit assembly, plays multiple roles in various intracellular events, including regulation of cell homeostasis, cell c...
Commander Complex—A Multifaceted Operator in Intracellular Signaling and Cargo
Commander Complex—A Multifaceted Operator in Intracellular Signaling and Cargo
Commander complex is a 16-protein complex that plays multiple roles in various intracellular events in endosomal cargo and in the regulation of cell homeostasis, cell cycle and imm...
PERCEPTION OF THE COMMUNITY OF MUARA TEWEH CITY NORTH BARITO DISTRICT AGAINST THE STRUGGLE COMMANDER OF BATUR
PERCEPTION OF THE COMMUNITY OF MUARA TEWEH CITY NORTH BARITO DISTRICT AGAINST THE STRUGGLE COMMANDER OF BATUR
For heroic values to be well embedded in people's lives, good knowledge is also needed regarding the history of the struggle carried out by Commander Batur against Dutch colonial...
Recovery of seed-dispersal interactions and functions in tropical forest ecosystems
Recovery of seed-dispersal interactions and functions in tropical forest ecosystems
Biodiversity includes species and their interactions, which together are fundamental to maintaining ecosystem functioning. At the community level, species interactions form complex...
Crystallographic and spectroscopic assessment of pharmaceutical material mechanics
Crystallographic and spectroscopic assessment of pharmaceutical material mechanics
<p>Despite the advent of alternative dosage forms, solid dosage forms constitute a major proportion of dosage forms not only on the market, but also in many pharmaceutical co...
Abstract 1816: Endogenous ADAMTS-13 regulates angiogenesis in cultured human endothelial cells
Abstract 1816: Endogenous ADAMTS-13 regulates angiogenesis in cultured human endothelial cells
Abstract
ADAMTS-13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13, is a zinc-containing metalloprotease that cleaves von Willebra...
THE LIEUTENANT COMMANDER POPIȘTEANU ALEXANDRU, COMMANDER OF THE HEROICAL 7 th FIGHTER GROUP IN THE AIR BATTLE FOR THE LIBERATION OF BASARABIA AND THE CONQUEST OF ODESSA
THE LIEUTENANT COMMANDER POPIȘTEANU ALEXANDRU, COMMANDER OF THE HEROICAL 7 th FIGHTER GROUP IN THE AIR BATTLE FOR THE LIBERATION OF BASARABIA AND THE CONQUEST OF ODESSA
Called by his qualities to become a flyer, a personality with a complex aeronautical training, being a graduate of the Romanian Higher War School and the French War School, with a ...
MARINE BENTHIC ALGAE FROM COMMANDER ISLANDS (REVISION 2020). I. CHLOROPHYTA AND OCHROPHYTA
MARINE BENTHIC ALGAE FROM COMMANDER ISLANDS (REVISION 2020). I. CHLOROPHYTA AND OCHROPHYTA
In Commander Islands, the peculiar geographic location, hydrology and geomorphology contributed to de-velopment of a very peculiar algal floristic complex. First scientific informa...