Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Synthesis and Cytotoxic Activity of Ursolic Acid Derivatives
View through CrossRef
10-15
Fourteen ursolic acid derivatives, among them four novel compounds, were synthesized by modification either at the C-3, C-28 or both positions. The cytotoxic activity of the obtained derivatives was evaluated against the four human cancer cell lines KB (human mouth epidermal carcinoma), HepG2 (human hepatocellular carcinoma), MCF7 (human breast carcinoma) and Lu (human lung carcinoma). As the result, compounds 7and 8were from two to three times more active than ursolic acid on all four tested cell lines. This is the first report on cytotoxic effects of the synthetized ursolic acid derivatives 4, 8, and .
Walter de Gruyter GmbH
Title: Synthesis and Cytotoxic Activity of Ursolic Acid Derivatives
Description:
10-15
Fourteen ursolic acid derivatives, among them four novel compounds, were synthesized by modification either at the C-3, C-28 or both positions.
The cytotoxic activity of the obtained derivatives was evaluated against the four human cancer cell lines KB (human mouth epidermal carcinoma), HepG2 (human hepatocellular carcinoma), MCF7 (human breast carcinoma) and Lu (human lung carcinoma).
As the result, compounds 7and 8were from two to three times more active than ursolic acid on all four tested cell lines.
This is the first report on cytotoxic effects of the synthetized ursolic acid derivatives 4, 8, and .
Related Results
Abstract A23: Novel ursolic acid derivatives with potent antitumor activity
Abstract A23: Novel ursolic acid derivatives with potent antitumor activity
Abstract
Cancer is the fourth leading cause of death worldwide, within pancreatic cancer is the fourth leading cause of cancer death and without effective medical th...
Ursolic acid: an overview including research performed in Peru
Ursolic acid: an overview including research performed in Peru
Ursolic acid (3β-3-hydroxy-urs-12-en-28-oic-acid) is a pentacyclic triterpenoid compound present in many medicinal herbs and edible fruits of different species of plants. U...
Synthesis and Antimicrobial Activity of Ursolic Acid Ester Derivatives
Synthesis and Antimicrobial Activity of Ursolic Acid Ester Derivatives
AbstractInfections caused by microorganisms are a major cause of morbidity and mortality worldwide, and natural products continue to be important sources for the discovery of new a...
Pharmacological screening of synthetic piperidine derivatives
Pharmacological screening of synthetic piperidine derivatives
Piperidine derivatives are essential heterocyclic compounds that have beneficial roles in the medical and commercial sector. They can be isolated from plant material and can be che...
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Evaluating the Science to Inform the Physical Activity Guidelines for Americans Midcourse Report
Abstract
The Physical Activity Guidelines for Americans (Guidelines) advises older adults to be as active as possible. Yet, despite the well documented benefits of physical a...
Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins
Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins
Background
Oligospermia is one of the most common reasons for male infertility which is troubling numerous couples of child-bearing age. This investigation scrutiniz...
Effects of Ursolic Acid on Colorectal Cancer: A Review of Recent Evidence
Effects of Ursolic Acid on Colorectal Cancer: A Review of Recent Evidence
Colorectal cancer is the third leading cause of cancer-related deaths, and the five-year survival rate of the metastatic disease is less than 15%. Treatment approaches include surg...
Synthesis of Ester‐Linked Ursolic Acid‐Based Hybrid Compounds: Potential Antibacterial and Anticancer Agents
Synthesis of Ester‐Linked Ursolic Acid‐Based Hybrid Compounds: Potential Antibacterial and Anticancer Agents
AbstractThe molecular hybridization of two or more drugs into a single molecule is an effective drug design approach to reduce pill burden and improve patient treatment adherence. ...