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Ursolic acid: an overview including research performed in Peru
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Ursolic acid (3β-3-hydroxy-urs-12-en-28-oic-acid) is a pentacyclic triterpenoid compound present in many medicinal herbs and edible fruits of different species of plants. Ursolic acid is now considered an important biomolecule due to its pharmacological activity and much of the research has focused on anticancer activity. To achieve the clinical application of ursolic acid, delivery nanosystems have been developed and the synthesis of its derivatives has also been carried out. In this review, we address different aspects of the chemistry of ursolic acid. Furthermore, we highlight the investigations that were carried out in Peru concerning ursolic acid.
Palavras-chave: Ursolic acid, Triterpenoid, Lamiaceae, Medicinal plants.
Abstract
El ácido ursólico (ácido 3β-hidroxi-urs-12-en-28-óico) es un triterpenoide pentacíclico presente en varias hierbas medicinales y frutos comestibles de diferentes especies de plantas, es considerado una importante biomolécula debido a su actividad farmacológica y gran parte de las investigaciones se han enfocado en su actividad anticancerígena. Para lograr la aplicación clínica del ácido ursólico, se han desarrollado nanosistemas para su administración y también se han sintetizado gran cantidad de derivados. En esta revisión abordamos diferentes aspectos de la química del ácido ursólico, y además, destacamos las investigaciones que se llevaron a cabo en el Perú.
Keywords: Ácido ursólico, Triterpenoide, Lamiaceae, Plantas medicinales.
Empresa Publica de Servicios Generales e Ingenieria Utm
Title: Ursolic acid: an overview including research performed in Peru
Description:
Ursolic acid (3β-3-hydroxy-urs-12-en-28-oic-acid) is a pentacyclic triterpenoid compound present in many medicinal herbs and edible fruits of different species of plants.
Ursolic acid is now considered an important biomolecule due to its pharmacological activity and much of the research has focused on anticancer activity.
To achieve the clinical application of ursolic acid, delivery nanosystems have been developed and the synthesis of its derivatives has also been carried out.
In this review, we address different aspects of the chemistry of ursolic acid.
Furthermore, we highlight the investigations that were carried out in Peru concerning ursolic acid.
Palavras-chave: Ursolic acid, Triterpenoid, Lamiaceae, Medicinal plants.
Abstract
El ácido ursólico (ácido 3β-hidroxi-urs-12-en-28-óico) es un triterpenoide pentacíclico presente en varias hierbas medicinales y frutos comestibles de diferentes especies de plantas, es considerado una importante biomolécula debido a su actividad farmacológica y gran parte de las investigaciones se han enfocado en su actividad anticancerígena.
Para lograr la aplicación clínica del ácido ursólico, se han desarrollado nanosistemas para su administración y también se han sintetizado gran cantidad de derivados.
En esta revisión abordamos diferentes aspectos de la química del ácido ursólico, y además, destacamos las investigaciones que se llevaron a cabo en el Perú.
Keywords: Ácido ursólico, Triterpenoide, Lamiaceae, Plantas medicinales.
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