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Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7, Figure S8, Table S1, Supplementary Materials and Methods from S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death
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<p>This file contains: Figure S1: Apoptosis determined by annexin V-FITC/7-AAD. Figure S2: NO prevents TNFa-induced classical NF-kB signaling pathway. Figure S3: Detection of S-nitrosylation of cIAP1 with the biotin-switch assay. Figure S4: Example of MALDI-TOF-MS spectra of S-nitrosylated cIAP1. Figure S5: SW480 stable cell line expressing 6myc-cIAP1-C571/574H. Figure S6: Characterization of apoptosis induced by GTN/TNFa. Figure S7: Functional analysis of the ubiquitin E3 ligase activity of cIAP1 mutants. Figure S8: NO prevents TNFa-mediated complex I to promote complex II. Table S1: TNFa concentration in media from human macrophages treated with 5-Fluorouracil/oxaliplatin. Supplementary Materials and Methods.</p>
American Association for Cancer Research (AACR)
Title: Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7, Figure S8, Table S1, Supplementary Materials and Methods from S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death
Description:
<p>This file contains: Figure S1: Apoptosis determined by annexin V-FITC/7-AAD.
Figure S2: NO prevents TNFa-induced classical NF-kB signaling pathway.
Figure S3: Detection of S-nitrosylation of cIAP1 with the biotin-switch assay.
Figure S4: Example of MALDI-TOF-MS spectra of S-nitrosylated cIAP1.
Figure S5: SW480 stable cell line expressing 6myc-cIAP1-C571/574H.
Figure S6: Characterization of apoptosis induced by GTN/TNFa.
Figure S7: Functional analysis of the ubiquitin E3 ligase activity of cIAP1 mutants.
Figure S8: NO prevents TNFa-mediated complex I to promote complex II.
Table S1: TNFa concentration in media from human macrophages treated with 5-Fluorouracil/oxaliplatin.
Supplementary Materials and Methods.
</p>.
Related Results
Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7, Figure S8, Table S1, Supplementary Materials and Methods from S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death
Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6, Figure S7, Figure S8, Table S1, Supplementary Materials and Methods from S-Nitrosylation of cIAP1 Switches Cancer Cell Fate from TNFα/TNFR1-Mediated Cell Survival to Cell Death
<p>This file contains: Figure S1: Apoptosis determined by annexin V-FITC/7-AAD. Figure S2: NO prevents TNFa-induced classical NF-kB signaling pathway. Figure S3: Detection of...
Small Cell Lung Cancer and Tarlatamab: A Meta-Analysis of Clinical Trials
Small Cell Lung Cancer and Tarlatamab: A Meta-Analysis of Clinical Trials
Abstract
Introduction
Tarlatamab is a Delta-like ligand 3 (DLL3) -directed bispecific T-cell engager recently approved for use in patients with advanced small cell lung cancer (SCL...
Intra-cluster receptor density (IRD) dictates TNFR1 clusters’ signaling efficacy
Intra-cluster receptor density (IRD) dictates TNFR1 clusters’ signaling efficacy
AbstractTumor Necrosis Factor Receptor 1 (TNFR1) signaling determines cell fate during inflammation, immunopathogenesis, and tumorigenesis. TNFR1 proteins homo-oligomerize into clu...
Abstract 1432: Tnfα ablation demonstrates no suppressive effect on inflammation-related mouse colon tumorigenesis
Abstract 1432: Tnfα ablation demonstrates no suppressive effect on inflammation-related mouse colon tumorigenesis
Abstract
Colorectal cancer (CRC) is one of the most serious complications of inflammatory bowel disease. Tumor necrosis factor-α (Tnfα) is a major mediator of inflam...
MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing v1
MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing v1
Human tissues comprise trillions of cells that populate a complex space of molecular phenotypes and functions and that vary in abundance by 4–9 orders of magnitude. Relying solely ...
TNFα‐induced activation of eosinophil oxidative metabolism and morphology ‐ Comparison with IL‐5*
TNFα‐induced activation of eosinophil oxidative metabolism and morphology ‐ Comparison with IL‐5*
Abstract Human dermal mast cells are capable of releasing cytokines, particularly preformed TNFα, upon appropriate stimulation. Masl cell activation in vivo was shown to be associa...
Poster 206: TIPE2 Mitigates the Histopathology of Osteoarthritis in An Accelerate Aging Mouse Model
Poster 206: TIPE2 Mitigates the Histopathology of Osteoarthritis in An Accelerate Aging Mouse Model
Objectives: It has been reported that pain occurs after the onset of OA and is often associated with inflammatory synovial expression of tumor necrotic factor (TNFα), suggesting th...
Pembrolizumab and Sarcoma: A meta-analysis
Pembrolizumab and Sarcoma: A meta-analysis
Abstract
Introduction: Pembrolizumab is a monoclonal antibody that promotes antitumor immunity. This study presents a systematic review and meta-analysis of the efficacy and safety...