Synthesis, X-ray Structure and Evaluation of Bactericidal Activity of an o-vanillin Functionalized Schiff Base

The present study reports the synthesis, crystal structure and evaluation of biological activities of a Schiff base, [L = (Z)-2-methoxy-6-(((2-methoxyphenyl) imino) methyl) phenol]. X-ray structure of Schiff base reveals that the compound crystallizes in the orthorhombic system with Pca space group. The Schiff base adopts two methoxy groups, one phenolic-OH and one azomethine group and exists in a Z-stereomer. Investigation on the self-assembled structure of the Schiff base exhibits the formation of a 3D supramolecular architecture through intermolecular O...H hydrogen bonding interactions. The bactericidal activity of the Schiff base has been examined against some pathogenic bacteria.