In vitro evaluation of novel designed, and synthesized naproxen derivatives bearing 1,2,4 triazole moiety

The Objective of this study is created a   novel derivative of the naproxen with the heterocyclic (1,2 and 4 the triazole) ring that reacted with benzoyl chloride derivatives, as well as preliminary antibacterial activity testing of the formed products. The derivatives are synthesized by esterifying naproxen hydrazine hydrate, then reacting with hydrated hydrazine and carbon disulfide, and finally reaction the benzoyl chloride derivatives (in the final step) with the triazole the derivatives of the naproxen including of amino group via a nucleophilic substitution reaction. In addition to naproxen, the antibacterial properties of the novel compounds (Va-Vd) were evaluated in agar at known doses (IN vivo). The antibacterial action of the compounds Va and Vd against staph was demonstrated in the topmost inhibited zone. In the case of E. coli, compound Vb has the smallest inhibitory zone. The findings of this study have implications to produce naproxen 1,2 and 4 the triazole-three-thiol derivatives, which reacted including the variety of benzoyl chloride derivatives. The potential of naproxen will be affected by the attraction of benzoyl chloride derivatives with para-groups on the benzen ring.