Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Recent Advances in Pathologic Research and Targeted Therapies of Thymoma
View through CrossRef
Thymoma is a rare tumor that was reclassified by the World Health Organization in 2015. Recent studies have made advances in molecular targeted therapies, such as c-KIT, EGFR, IGF-1R, PTEN, HDAC, VEGF and PD-L1. Additionally, new molecular markers such as CTV/CTS, GTF2I, Pax8 and DSG-3 have been used in the differential diagnosis of thymoma. This article reviews molecular pathogenesis of thymoma, application of molecular pathology in the differential diagnosis of thymoma and recent progress in targeted therapies for thymoma.
Title: Recent Advances in Pathologic Research and Targeted Therapies of Thymoma
Description:
Thymoma is a rare tumor that was reclassified by the World Health Organization in 2015.
Recent studies have made advances in molecular targeted therapies, such as c-KIT, EGFR, IGF-1R, PTEN, HDAC, VEGF and PD-L1.
Additionally, new molecular markers such as CTV/CTS, GTF2I, Pax8 and DSG-3 have been used in the differential diagnosis of thymoma.
This article reviews molecular pathogenesis of thymoma, application of molecular pathology in the differential diagnosis of thymoma and recent progress in targeted therapies for thymoma.
Related Results
Genetic characterization of thymoma
Genetic characterization of thymoma
AbstractThymoma represents the most common anterior mediastinal compartment neoplasm, originating from the epithelial cell population in the thymus. Various histological types of t...
YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma
YAP1-MAML2 Fusion as a Diagnostic Biomarker for Metaplastic Thymoma
BackgroundMetaplastic thymoma is a very rare tumor with only a few case reports documented in literature. Hence, its molecular features have not been well explored.Material and Met...
Investigation of the prognostic biomarkers for thymoma
Investigation of the prognostic biomarkers for thymoma
Abstract
Background
Thymoma represents the most common anterior mediastinal malignancy and has a close association with autoimmune disease. However, the potential molecula...
Clinical and Genetic Characteristics of Thymoma Patients With Autoimmune Hepatitis and Myocarditis
Clinical and Genetic Characteristics of Thymoma Patients With Autoimmune Hepatitis and Myocarditis
BackgroundOur study investigated a special series of thymoma with autoimmune hepatitis and myocarditis and tried to reveal the gene expression profiles of this series of thymoma.Me...
Aplastic Anemia Proceeding to Thymoma: A Rare Co‐Occurrence—A Case Report and Review Article
Aplastic Anemia Proceeding to Thymoma: A Rare Co‐Occurrence—A Case Report and Review Article
Background
Malignant thymoma is a rare tumor associated with various paraneoplastic syndromes, such as myasthenia gravis, pure red cell aplasia, and hypogammagl...
Investigation of Motor End Plate Functions in Individuals with Incidentally Detected Thymoma
Investigation of Motor End Plate Functions in Individuals with Incidentally Detected Thymoma
Purpose: Thymoma is a mediastinal tumor that is frequently associated with Myasthenia Graves (MG) and develops from thymic epithelial cells. In our study, we aimed to determine whe...
Case Report : Thymoma Mimicking Teratoma Clinically and Radiographic Appearance
Case Report : Thymoma Mimicking Teratoma Clinically and Radiographic Appearance
Background: Thymoma is a rare tumor of thymic epithelial cells in anterior mediastinum. The etiology of thymoma is not known with certainty. Thymomas are difficult to distinguish f...
Nodular Development of Spontaneous Epithelial Thymoma in (ACI/NMs × BUF/Mna)F1 Rats
Nodular Development of Spontaneous Epithelial Thymoma in (ACI/NMs × BUF/Mna)F1 Rats
The BUF/Mna strain is a high thymoma line of rats, and virtually all rats develop overt thymomas by the age of 40 weeks. To reveal the early morphologic changes in this thymomagene...