Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Encoding of locomotion kinematics in the mouse cerebellum
View through CrossRef
Abstract
The cerebellum has a well-established role in locomotion control, but how the cerebellar network regulates locomotion behaviour is still not well understood. We therefore characterized the activity of cerebellar neurons in awake mice engaged in a locomotion task, using high-density silicon electrode arrays. We characterized the activity of over 300 neurons in response to locomotion, finding tuning to speed of locomotion, turning, and phase of the step cycle. We found that the cerebellar neurons we recorded mainly encoded information about future locomotor activity. We were able to decode the speed of locomotion with a simple linear algorithm, needing relatively few well-chosen cells to provide an accurate estimate of locomotion speed. Our observation that cerebellar neuronal activity predicts locomotion in the near future, and encodes the required kinematic variables, points to this activity underlying the efference copy signal for vertebrate locomotion.
Title: Encoding of locomotion kinematics in the mouse cerebellum
Description:
Abstract
The cerebellum has a well-established role in locomotion control, but how the cerebellar network regulates locomotion behaviour is still not well understood.
We therefore characterized the activity of cerebellar neurons in awake mice engaged in a locomotion task, using high-density silicon electrode arrays.
We characterized the activity of over 300 neurons in response to locomotion, finding tuning to speed of locomotion, turning, and phase of the step cycle.
We found that the cerebellar neurons we recorded mainly encoded information about future locomotor activity.
We were able to decode the speed of locomotion with a simple linear algorithm, needing relatively few well-chosen cells to provide an accurate estimate of locomotion speed.
Our observation that cerebellar neuronal activity predicts locomotion in the near future, and encodes the required kinematic variables, points to this activity underlying the efference copy signal for vertebrate locomotion.
Related Results
Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement
Auditory cortex ensembles jointly encode sound and locomotion speed to support sound perception during movement
The ability to process and act upon incoming sounds during locomotion is critical for survival and adaptive behavior. Despite the established role that the auditory cortex (AC) pla...
Ca functional imaging from the cerebellum to the vestibular end‐organs
Ca functional imaging from the cerebellum to the vestibular end‐organs
Objectives
The calcium ion plays a major role in the inner ear and the cerebellum. But in vivo calcium metabolism is still unknown problems in these areas. Thou...
Integration of sound and locomotion information by auditory cortical neuronal ensembles
Integration of sound and locomotion information by auditory cortical neuronal ensembles
Abstract
The ability to process and act upon incoming sounds during locomotion is critical for survival. Intriguingly, sound responses of auditory cortical neurons ...
Neuropeptidergic regulation of locomotion inhibition in C. elegans
Neuropeptidergic regulation of locomotion inhibition in C. elegans
Locomotion, the way animals independently move through space by active muscle contractions, is one of the most apparent animal behaviors. However, in many situations it is more ben...
The evolution of femoral specializations in dinosaurs and their cousins in relation to their locomotor habit and body mass
The evolution of femoral specializations in dinosaurs and their cousins in relation to their locomotor habit and body mass
L'évolution des spécialisations du fémur des dinosaures et de leurs cousins en fonction de leur mode de locomotion et masse corporelle.
Les archosaures actuels, rep...
Artificial cerebellum on FPGA: Realistic real-time cerebellar spiking neural network model capable of real-world adaptive motor control
Artificial cerebellum on FPGA: Realistic real-time cerebellar spiking neural network model capable of real-world adaptive motor control
Abstract
The cerebellum plays a central role in motor control and learning. Its neuronal network architecture, firing characteristics of componen...
The Effect of the Accuracy of Various Measuring Devices on Recorded Joint Kinematics
The Effect of the Accuracy of Various Measuring Devices on Recorded Joint Kinematics
Knowledge of joint kinematics contributes to the understanding of the function of soft tissue restraints, injury mechanisms, and can be used to evaluate surgical repair techniques....
Locomotion analysis identifies roles of mechanosensory neurons in governing locomotion dynamics of C. elegans
Locomotion analysis identifies roles of mechanosensory neurons in governing locomotion dynamics of C. elegans
Summary
The simple and well-characterized nervous system of C. elegans facilitates analysis of mechanisms controlling behavior. Locomotion is a major behavioral outp...