Pengaruh filtrat fermentasi nira kelapa (Cocos nucifera L.), nira jaka (Arenga pinnata), nira ental (Borassus flabellifer), dan ubi jalar ungu (Ipomoea batatas L.) terhadap ketebalan epidermis kulit tikus Wistar yang dipapar sinar UVB

Background: Skin aging is influenced by various factors, one of which is UV rays. Photoaging can cause thinning of the epidermis. Fermented products are known to inhibit the reduction in epidermis thickness. This study aims to identify the effect of fermented filtrate of coconut palm wine, jaka palm wine, ental palm wine and purple sweet potato on the thickness of the skin epidermis of Wistar rats exposed to UVB rays. Methods: Post test only control group is the design of this research. The samples used in this research were 51 Wistar rats divided into 17 groups with treatment for one month. The control group was exposed to UVB 840 mJ and given a smear of aquabidest. The treatment group was given UVB 840 mJ and fermented filtrate of coconut palm wine, jaka palm wine, ental palm wine and purple sweet potato with concentrations of 25%, 50%, 75% and 100%. Results: The differences of epidermis thickness were found significant (p<0.05) between the control group (mean thickness 37.05mm) and the coconut palm wine fermentation filtrate treatment group with concentrations of 50% (mean thickness 48.94mm), 75% (mean thickness 52.94mm), palm wine fermentation filtrate with a concentration of 50% (average thickness 47.83mm) and purple sweet potato with a concentration of 25% (average thickness 51.73mm). Conclusion: Fermented filtrate of coconut palm wine 50% and 75%, jaka palm wine 50% and purple sweet potato 25% inhibits the decrease in the thickness of the skin epidermis of Wistar rats exposed to UVB light.   Latar Belakang: Penuaan kulit dipengaruhi oleh berbagai faktor salah satunya adalah sinar UV. Photoaging dapat menyebabkan penipisan epidermis. Produk fermentasi diketahui dapat menghambat penurunan ketebalan epidermis. Penelitian ini bertujuan untuk mengidentifikasi pengaruh filtrat fermentasi nira kelapa, nira jaka, nira ental dan ubi jalar ungu terhadap ketebalan epidermis kulit tikus wistar yang dipapar sinar UVB. Metode: Post test only control group merupakan desain penelitian ini. Sampel yang digunakan dalam penelitian ini adalah 51 ekor tikus wistar yang dibagi menjadi 17 kelompok dengan perlakuan selama satu bulan. Kelompok kontrol dipapar UVB 840 mJ dan diberikan olesan aquabides. Kelompok perlakuan diberikan UVB 840 mJ dan filtrat fermentasi nira kelapa, nira jaka, nira ental dan ubi jalar ungu dengan konsentrasi 25%, 50%, 75%, dan 100%. Hasil Penelitian: Perbedaan rerata ketebalan epidermis yang signifikan (sig.< 0,05) antara kelompok kontrol (rerata ketebalan 37,05 mm) terhadap kelompok perlakuan filtrat fermentasi nira kelapa dengan konsentrasi 50% (rerata ketebalan 48,94 mm), 75% (rerata ketebalan 52,94 mm), filtrat fermentasi nira jaka dengan konsentrasi 50% (rerata ketebalan 47,83 mm) dan ubi jalar ungu dengan konsentrasi 25% (rerata ketebalan 51,73 mm). Kesimpulan: Filtrat fermentasi nira kelapa 50% dan 75%, nira jaka 50%, dan fermentasi ubi jalar ungu 25% menghambat penurunan ketebalan epidermis kulit tikus Wistar yang dipapar sinar UVB