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Chitinases: Therapeutic Scaffolds for Allergy and Inflammation
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Background:
Chitinases are the evolutionary conserved glycosidic enzymes that are characterized
by their ability to cleave the naturally abundant polysaccharide chitin. The potential role of
chitinases has been identified in the manifestation of various allergies and inflammatory diseases. In
recent years, chitinases inhibitors are emerging as an alluring area of interest for the researchers and
scientists and there is a dire need for the development of potential and safe chitinase antagonists for the
prophylaxis and treatment of several diseases.
Objective:
The present review expedites the role of chitinases and their inhibitors in inflammation and
related disorders.
Methods:
At first, an exhaustive survey of literature and various patents available related to chitinases
were carried out. Useful information on chitinases and their inhibitor was gathered from the authentic
scientific databases namely SCOPUS, EMBASE, PUBMED, GOOGLE SCHOLAR, MEDLINE, EMBASE,
EBSCO, WEB OF SCIENCE, etc. This information was further analyzed and compiled up to
prepare the framework of the review article. The search strategy was conducted by using queries with
key terms “ chitin”, “chitinase”, “chitotrisidase”, “acidic mammalian chitinase”, “chitinase inhibitors”,
“asthma” and “chitinases associated inflammatory disorders”, etc. The patents were searched using the
key terms “chitinases and uses thereof”, “chitinase inhibitors”, “chitin-chitinase associated pathological
disorders” etc. from www.google.com/patents, www.freepatentsonline.com, and www.scopus.com.
Results:
The present review provides a vision for apprehending human chitinases and their participation
in several diseases. The patents available also signify the extended role and effectiveness of chitinase
inhibitors in the prevention and treatment of various diseases viz. asthma, acute and chronic inflammatory
diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases,
polycystic ovary syndrome, endometriosis, and cancer. In this regard, extensive pre-clinical and
clinical investigations are required to develop some novel, potent and selective drug molecules for the
treatment of various inflammatory diseases, allergies and cancers in the foreseeable future.
Conclusion:
In conclusion, chitinases can be used as potential biomarkers in prognosis and diagnosis of
several inflammatory diseases and allergies and the design of novel chitinase inhibitors may act as key
and rational scaffolds in designing some novel therapeutic agents in the treatment of variety of inflammatory
diseases.
Bentham Science Publishers Ltd.
Title: Chitinases: Therapeutic Scaffolds for Allergy and Inflammation
Description:
Background:
Chitinases are the evolutionary conserved glycosidic enzymes that are characterized
by their ability to cleave the naturally abundant polysaccharide chitin.
The potential role of
chitinases has been identified in the manifestation of various allergies and inflammatory diseases.
In
recent years, chitinases inhibitors are emerging as an alluring area of interest for the researchers and
scientists and there is a dire need for the development of potential and safe chitinase antagonists for the
prophylaxis and treatment of several diseases.
Objective:
The present review expedites the role of chitinases and their inhibitors in inflammation and
related disorders.
Methods:
At first, an exhaustive survey of literature and various patents available related to chitinases
were carried out.
Useful information on chitinases and their inhibitor was gathered from the authentic
scientific databases namely SCOPUS, EMBASE, PUBMED, GOOGLE SCHOLAR, MEDLINE, EMBASE,
EBSCO, WEB OF SCIENCE, etc.
This information was further analyzed and compiled up to
prepare the framework of the review article.
The search strategy was conducted by using queries with
key terms “ chitin”, “chitinase”, “chitotrisidase”, “acidic mammalian chitinase”, “chitinase inhibitors”,
“asthma” and “chitinases associated inflammatory disorders”, etc.
The patents were searched using the
key terms “chitinases and uses thereof”, “chitinase inhibitors”, “chitin-chitinase associated pathological
disorders” etc.
from www.
google.
com/patents, www.
freepatentsonline.
com, and www.
scopus.
com.
Results:
The present review provides a vision for apprehending human chitinases and their participation
in several diseases.
The patents available also signify the extended role and effectiveness of chitinase
inhibitors in the prevention and treatment of various diseases viz.
asthma, acute and chronic inflammatory
diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases,
polycystic ovary syndrome, endometriosis, and cancer.
In this regard, extensive pre-clinical and
clinical investigations are required to develop some novel, potent and selective drug molecules for the
treatment of various inflammatory diseases, allergies and cancers in the foreseeable future.
Conclusion:
In conclusion, chitinases can be used as potential biomarkers in prognosis and diagnosis of
several inflammatory diseases and allergies and the design of novel chitinase inhibitors may act as key
and rational scaffolds in designing some novel therapeutic agents in the treatment of variety of inflammatory
diseases.
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