A COMPARISON OF CEFTRIAXONE AND CIPROFLOXACIN’S EFFICACY IN THE TREATMENT OF GONORRHOEA

Introduction: A bacterial illness that is extremely infectious and spreads via sexual contact between men and women,gonorrhea is a serious public health problem. It is among the most ancient sexually transmitted infections (STDs), andNeisseria is the cause. Rarely, gonorrhea may also result in pharyngeal, ocular, articular, and dermatological diseasesin addition to its predominant urogenital signs and symptoms. Various antibiotics, including spectinomycin, penicillins,tetracyclines, macrolides, fluoroquinolones, and sulpha medicines, have been used to treat gonorrhea. Some of thesemedicines have become less effective in treating gonorrhea due to an increase in resistant infections.Objective: This research compared the efficaciousness of Ceftriaxone and Ciprofloxacin in managing gonococcalinfections.Study Design: Observational Study.Place of Duration of Study: The research was carried out from January 2003 to March 2004 at the NewGulail Polyclinic in Saudi Arabia.Material and Methods: With the Institutional Ethical Committee’s consent, 200 patients received Ceftriaxoneand Ciprofloxacin to treat gonorrhea. Enrolling the patients included the use of a purposeful sampling approach. Everypatient was split into two groups of 100 individuals, each at random. Group B received a single intravenous dose of500 mg of Ceftriaxone injection, whereas Group A received a 500 mg tablet of Ciprofloxacin. After five days, allof the patients had follow-up exams, and the results of their lab and clinical examinations were noted and evaluated.Results: Patients in Group A (n=100) receiving Ciprofloxacin demonstrated 80% full response, 9% partial response,and 11% no response on the fifth day after treatment. In contrast, patients in Group B (n=100) receiving Ceftriaxonedemonstrated 90% full response, 4% partial response, and 6% no response.Conclusion: Ceftriaxone has shown superior efficacy in treating gonorrhea when compared to Ciprofloxacin. Aftertaking an antibiotic for the first time, it is advised that all patients have another examination to check that the gonorrhea has completely healed.Key Words: Neisseria gonorrhea, sexually transmitted infection (STI), Sexually Transmitted Disease