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Further extension of mammalian GATA‐6
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Mammalian GATA‐6, which has conserved tandem zinc fingers (CVNC‐X17‐CNAC)‐X29‐(CXNC‐X17‐CNAC), is essential for the development and specific gene regulation of the heart, gastrointestinal tract and other tissues. GATA‐6 recognizes the (A/T/C)GAT(A/T)(A) sequence, and interacts with other transcriptional regulators through its zinc‐finger region. The mRNA of GATA‐6 uses two Met codons in frame as translational initiation codons, and produces L‐ and S‐type GATA‐6 through leaky ribosome scanning. GATA‐6 is subjected to cAMP‐dependent proteolysis by a proteasome in a heterologous expression system. These protein‐based characteristics of GATA‐6 will be helpful for the identification of target genes, together with determination of the in vivo binding sites for GATA‐6 and understanding of the complex network of gene regulation mediated by GATA‐6.
Title: Further extension of mammalian GATA‐6
Description:
Mammalian GATA‐6, which has conserved tandem zinc fingers (CVNC‐X17‐CNAC)‐X29‐(CXNC‐X17‐CNAC), is essential for the development and specific gene regulation of the heart, gastrointestinal tract and other tissues.
GATA‐6 recognizes the (A/T/C)GAT(A/T)(A) sequence, and interacts with other transcriptional regulators through its zinc‐finger region.
The mRNA of GATA‐6 uses two Met codons in frame as translational initiation codons, and produces L‐ and S‐type GATA‐6 through leaky ribosome scanning.
GATA‐6 is subjected to cAMP‐dependent proteolysis by a proteasome in a heterologous expression system.
These protein‐based characteristics of GATA‐6 will be helpful for the identification of target genes, together with determination of the in vivo binding sites for GATA‐6 and understanding of the complex network of gene regulation mediated by GATA‐6.
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