Curcumin anti-inflammatory and antitumorigenic effect on arteriovenous fistula maturation in patient with end-stage renal disease with diabetes mellitus

The primary clinical problem of arteriovenous fistula (AVF) is the high maturation failure rate. Curcumin shows anti-inflammatory, antioxidant, antitumorigenic, and antiproliferative effects that may contribute to AVF maturation.  This study investigated the effectiveness of curcumin and acetylsalicylic acid on anti-inflammatory and antitumorigenic effects on AVF maturation in patients with End-Stage Renal Disease (ESRD) with diabetes mellitus (DM).  The present study is a single-blinded, randomized controlled trial consisting of curcumin, acetylsalicylic acid, or placebo intervention for eight weeks. A total of 67 participants completed the intervention. There was a higher level of nitric oxide (NO) between the curcumin and placebo four weeks (92.58±24.70 vs 75.67±16.50 µmol/L, adjusted p = 0.038) and eight weeks (95.27±28.77 vs 76.66±23.24 µmol/L, adjusted p <0.05) postoperatively. Higher-level of NO between acetylsalicylic acid and placebo (93.65±24.65 vs 75.67±16.50 µmol/L, adjusted p = 0.031) four weeks postoperatively. Curcumin increases NO after four and eight weeks and lowers MMP-9 four weeks after AVF operation. Acetylsalicylic acid increases NO four weeks after AVF surgery on ESRD patients with DM.