Effects of Allium siculum in ethylene glycol induced kidney stone in male albino rats

This study attempts to find out the curative effects of Allium siculum (A. siculum) on ethylene glycol (EG) induced kidney stone in male albino rats. Throughout this study, twenty-two male albino rats were taken and divided into four experimental groups. Group A is a control group, while the rest of the groups, namely group B, C, and D animals, received 1% EG in water for 14 days, then from day 15 to day 28, the treatment of EG stopped and group C and D animals from day 15 to day 28 received A. siculum (5g of dried powder in 100 ml water and 950 g standard diet) and cystone (2.5 tablets in water and standard diet) respectively. Serum uric acid, creatinine, urea, lipid profile measurements, and glucose were evaluated besides the kidneys' weight and body weight gain. Allium siculum and cystone treatments indicated a significant reduction in serum uric acid, creatinine, urea, glucose, very low-density lipoprotein, and triglyceride compared to EG-treated rats. The kidneys' weight and body weight gains significantly increased in group B compared with A, C, and D. In conclusion: A. siculum has curative effects on ethylene glycol induced kidney stone which resembled the cystone drug.