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Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction
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A simple and sensitive spectrophotometric method was developed for the determination of Methyl Paraben via oxidative coupling with the 2,4-Dinitrophynel hydrazine in the presence of N-bromosuccinimid in a basic medium, Absorbance of the obtained coloured products was measured at the corresponding optimum wavelengths (600 nm), Beer’s law is obeyed over the concentration of 2.0-20 μg.ml-1, and The molar absorptivity of (6253 L.mole-1.cm-1), Sandell,s sensitity index of (0.02433 µg.cm-2). The detection limits were (0.34 μg.ml-1), with a linear regression correlation coefficient of (0.9947) and recovery range from (98.96–103%). The proposed method has been applied successfully to determine Methyl Paraben in pharmaceutical preparations and cosmetic formulations.
Title: Spectrophotometric Determination of Methyl Paraben in Pharmaceutical Formulations by Oxidative Coupling Reaction
Description:
A simple and sensitive spectrophotometric method was developed for the determination of Methyl Paraben via oxidative coupling with the 2,4-Dinitrophynel hydrazine in the presence of N-bromosuccinimid in a basic medium, Absorbance of the obtained coloured products was measured at the corresponding optimum wavelengths (600 nm), Beer’s law is obeyed over the concentration of 2.
0-20 μg.
ml-1, and The molar absorptivity of (6253 L.
mole-1.
cm-1), Sandell,s sensitity index of (0.
02433 µg.
cm-2).
The detection limits were (0.
34 μg.
ml-1), with a linear regression correlation coefficient of (0.
9947) and recovery range from (98.
96–103%).
The proposed method has been applied successfully to determine Methyl Paraben in pharmaceutical preparations and cosmetic formulations.
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