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To control the para-Hydroxybenzoic Acid during the synthesis of Sodium Methyl Paraben Preservative
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Sodium Methyl Paraben (SMP) is the sodium salt of Methyl Paraben. Para-Hydroxybenzoic acid is most common Degradation impurity of Sodium Methyl Paraben. There are several mechanisms involves the formation of Para-Hydroxybenzoic Acid (PHBA) as an impurity during Sodium Methyl Paraben (SMP) synthesis. Mainly Parent paraben readily undergo base-catalyzed hydrolysis of the ester bond, forming PHBA. Solvent may affect the formation of PHBA, mainly the role of Methanol.
Title: To control the para-Hydroxybenzoic Acid during the synthesis of Sodium Methyl Paraben Preservative
Description:
Sodium Methyl Paraben (SMP) is the sodium salt of Methyl Paraben.
Para-Hydroxybenzoic acid is most common Degradation impurity of Sodium Methyl Paraben.
There are several mechanisms involves the formation of Para-Hydroxybenzoic Acid (PHBA) as an impurity during Sodium Methyl Paraben (SMP) synthesis.
Mainly Parent paraben readily undergo base-catalyzed hydrolysis of the ester bond, forming PHBA.
Solvent may affect the formation of PHBA, mainly the role of Methanol.
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