Aktivitas Pertumbuhan Rambut Hair Tonic Ekstrak Daun Bandotan (Ageratum conyzoides L.) Pada Kelinci Jantan (Oryctolagus Cuniculus)

AbstractHair loss is a disorder or disorder of hair apart from the scalp or body skin so that it interferes with various biological functions of hair on the body. Types of hair care cosmetic that is effective in dealing with hair loss are hair tonic. Hair tonic is a preparation for the treatment of the scalp and hair. Bandotan (Ageratum conyzoides L.) is used by the public as medicine and hair care. The purpose of this study was to determine the formulation of hair tonic preparations from the ethanol extract of bandotan leaves according to the requirements and hair growth activity of local male rabbits. The extraction method used the maceration method with 96% ethanol and applied hair tonic extract of bandotan leaves on the skin of local male rabbits (Oryctolagus cuniculus) which were treated as blanks without smearing, positive control (Natur), negative control hair tonic base, concentration bandotan leaf extract. (5%, 10%, 15% and 20%) for 21 days. The data obtained in the form of hair length, and hair weight. Analysis of the data obtained for hair growth activity was seen from the results of the ANOVA test and continued with the BNT test (Least Significance Different). The results of the research for evaluating hair tonic preparations included organoleptic tests, pH tests, viscosity tests, specific gravity tests, and cycling tests. Hair tonic ethanol extract of bandotan leaves has hair growth activity. Hair tonic ethanol extract of bandotan leaves with a concentration of 20% had the highest hair length and hair weight. From the results of one way ANOVA, a significant value was obtained 0.000 < 0.005, so it was concluded that there was a significant difference between treatments, and continued with the BNT test (Least Significance Different) positive control was not significantly different from hair tonic concentration of 20%.Keywords: Bandotan leaves, Hair tonic, Hair growth AbstrakKerontokan rambut adalah suatu gangguan atau kelainan rambut terlepas dari kulit kepala atau kulit tubuh sehingga mengganggu berbagai fungsi biologis rambut terhadap tubuh. Jenis kosmetik perawatan rambut yang efektif mengatasi rambut rontok adalah hair tonic. Hair tonic adalah sediaan untuk perawatan kulit kepala dan rambut. Bandotan (Ageratum conyzoides L.) digunakan oleh masyarakat sebagai obat dan perawatan rambut. Tujuan dari penelitian ini mengetahui formulasi sediaan hair tonic dari ekstrak etanol daun bandotan yang sesuai dengan persyaratan dan aktivitas pertumbuhan rambut pada kelinci jantan lokal. Metode ekstraksi menggunakan metode maserasi dengan etanol 96% dan dilakukan pengolesan hair tonic ekstrak daun bandotan pada kulit kelinci jantan lokal (Oryctolagus cuniculus) yang diberikan perlakuan sebagai blanko tanpa pengolesan, kontrol positif (Natur), kontrol negatif basis hair tonic, ekstrak daun bandotan konsentrasi (5%,10%,15% dan 20%) selama 21 hari. Data yang diperoleh berupa panjang rambut, dan bobot rambut. Analisa data yang diperoleh untuk aktivitas pertumbuhan rambut dilihat dari hasil uji ANOVA dan dilanjutkan dengan uji BNT (Beda Nyata Terkecil). Hasil penelitian untuk evaluasi sediaan hair tonic antara lain uji organoleptis, uji pH, uji viskositas, uji bobot jenis, dan uji cycling test. Hair tonic ekstrak etanol daun bandotan memiliki aktivitas pertumbuhan rambut. Hair tonic ekstrak etanol daun bandotan dengan konsentrasi 20% memiliki panjang rambut dan bobot rambut tertinggi. Dari hasil one way ANOVA didapatkan nilai signifikan 0,000 < 0,005 sehingga disimpulkan adanya perbedaan signifikan antar perlakuan, dan dilanjutkan uji BNT (Beda Nyata Terkecil) didapatkan kontrol positif tidak berbeda nyata dengan hair tonic konsentrasi 20%.Kata kunci : Daun bandotan; Hair tonic; Pertumbuhan rambut