Correlation between peripheral immature platelet level and coronary immature platelet levels in coronary artery disease: an observational study in cardiac referral centre in East Java, Indonesia

Objective: To investigate the correlation between peripheral and coronary immature platelet, and factors that maypredict coronary immature platelet levels.Method: The cross-sectional, observational, analytical study was conducted at the Cardiovascular Diagnostic andIntervention Centre of Dr Soetomo General Academic Hospital, Surabaya, Indonesia, from November 2017 toJanuary 2018, and comprised patients of either gender with coronary artery disease. Peripheral and coronary bloodsamples were retrieved during coronary catheterisation. Immature platelet fraction was acquired by examiningwhole blood samples analysed through automated flow cytometry. Relationship between peripheral and coronaryimmature platelet fractions and counts were analysed using parametric correlation test, followed by linearregression analysis model of variables that influenced coronary immature platelet fraction. The statistical analysiswas carried out using SPSS Statistics for Windows, Version 25.0 (IBM Corp, Armonk, NY, USA).Results: Of the 70 patients, 55(78.6%) were males and 15(21.4%) were females. The overall mean age was 57±5.32years. There were 35(50%) patients with a history of smoking, and 34(48.6%) had hypertension and dyslipidaemia.Mean peripheral immature platelet fraction was 3.86±1.84% and mean coronary immature platelet fraction was3.63±1.7%. There was a robust positive and significant correlation (r=0.882; p<0.001) between immature plateletlevels in peripheral and coronary blood. Peripheral immature platelet and glycated haemoglobin >7.5 wereindependent predictors of coronary immature platelet (p=0.001).Conclusion: There was a strong correlation between immature platelet levels in peripheral and coronary blood.Key Words: Haemoglobin, Platelets, Coronary vessels, Heart.