Double Dose versus Standard Dose of Tamsulosin with Solifenacin for Treatment of Ureteric SRS (Stent Related Symptoms)

Abstract Background Ureteral stents provide drainage of the upper urinary tract, when obstruction of the ureter is present or anticipated. Indicated in relieving urinary obstruction, following or prior to ureterorenoscopy, Prophylactic before ESWL, Conservative Treatment of Upper Urinary Tract Trauma to reduces urinary leakage and the risk of strictures, Reconstructive Surgery of the Upper Urinary Tract and identifying the ureter before specific abdominal surgeries. Stent-related symptoms have a high prevalence. They include irritative voiding symptoms including frequency, urgency, dysuria, incomplete emptying; flank and suprapubic pain; incontinence, and hematuria. Objective To evaluate the effectiveness of Double dose versus standard dose of tamsulosin with solifenacin in relieving stent related symptoms. Patients and Methods A Randomized controlled clinical trial was conducted on 64 Egyptian patients from the outpatient clinic and inpatients Urology department of Ain Shams University Hospital for Six months. Results After 2 weeks of medication, the double dose of tamsulosin with solifenacin was more effective for stent-related symptoms than standard dose. There was significant difference in the score between the double dose and the standard dose. Side effects were more frequent among the double dose group with significant difference only in retrograde ejaculation and dry mouth. Conclusion Combination therapy of Tamsulosin with solifenacin is effective in relieving stent related symptoms. In some patients who are still complaining even with this combination we can double the dose of tamsulosin and solifinacin in order to relieve the symptoms even if the temporary and accepted side effects will increase.