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Transdermal Microneedle Patch for Antioxidants Release

Abstract Polymer based microneedle transdermal drug delivery system fits the criterion for an efficient patient compliant drug delivery system of the future. We demonstrate a polymer-based microneedle drug release transdermal platform fabricated via layer by layer (LbL) assembly of conductive polydimethylsiloxane integrated with carbon nanotubes, cellulose nanocrystal and polyaniline (PDMS@CNT/CNC@PANI). The electrically conductive PDMS@CNT/CNC@PANI microneedle patch provides a platform for drug loading, stabilization and transdermal controlled drug release. The drug loaded PDMS@CNT/CNC@PANI microneedle patch was evaluated for diffusion and voltage mediated transdermal delivery of thymol blue and rutin as model compounds. Chicken skin was used as an analogue of human skin.

Springer Science and Business Media LLC

Samuel Mugo Scott Roberston Weihao Lu

2024

Title: Transdermal Microneedle Patch for Antioxidants Release

Description:

Abstract Polymer based microneedle transdermal drug delivery system fits the criterion for an efficient patient compliant drug delivery system of the future.

We demonstrate a polymer-based microneedle drug release transdermal platform fabricated via layer by layer (LbL) assembly of conductive polydimethylsiloxane integrated with carbon nanotubes, cellulose nanocrystal and polyaniline (PDMS@CNT/CNC@PANI).

The electrically conductive PDMS@CNT/CNC@PANI microneedle patch provides a platform for drug loading, stabilization and transdermal controlled drug release.

The drug loaded PDMS@CNT/CNC@PANI microneedle patch was evaluated for diffusion and voltage mediated transdermal delivery of thymol blue and rutin as model compounds.

Chicken skin was used as an analogue of human skin.

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Transdermal Microneedle Patch for Antioxidants Release

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