Estimation of Antihyperglycemic and Antihyperlipidemic Activity of Isolated Fractions from Ficus glomerata Bark Extract in Streptozotocin-Induced Diabetic Rats

Ficus glomerata is commonly used for the treatment of diabetes. We planned to isolate compound from the ethanol extract of F. glomerata bark, and also evaluate the antidiabetic activity of isolated fractions in Streptozotocin (STZ)-induced diabetic rats.  Oral administration of ethanol extract of bark and root of F. glomerata at the doses of 200 and 400 mg/kg body weight was studied in STZ-induced diabetic rats. After administration of extract the fasting blood glucose levels were significantly decreased. The eight different fractions were collected from ethanol extract of F. glomerata bark and dried. The fraction F4, F5, F6, F7 and F9 were administered orally in Streptozotocin (STZ)-induced diabetic rats. After the administration of fractions, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered. The effect of fractions on induced hyperlipidemia was analyzed where the fraction significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the High density lipoprotein (HDL). Glibenclamide was used as a standard drug at a dose of 0.50 mg/kg body weight. Moreover, the fraction treated rats exhibited the significant rise in serum insulin level compared with streptozotocin- induced diabetic rats. The findings demonstrated that fraction isolated from ethanol extracts of F. glomerata bark has significant antidiabetic activity in streptozotocin-induced rats compared to standard drug. These results indicated that F. glomerata possesses significant antidiabetic and antihyperlipidemic effect due to presence of these fractions.