Soft, Transparent and Bioresorbable Microelectrode Array for Transient Electrophysiological Recordings

Abstract Transparent microelectrode arrays that enable multimodal investigation of spatiotemporal electrophysiological activity are critical tools for advancing the understanding of excitable tissues such as the brain, heart, and peripheral nerves. Traditional implantable devices are engineered for chronic use but require surgical removal when they fail or are no longer needed. In contrast, bioresorbable systems that naturally dissolve after serving temporary functions offer a compelling alternative, eliminating the risks and costs of extraction procedures. Here, we present the design, fabrication, and validation of a soft, fully bioresorbable, and optically transparent MEA platform for transient, bidirectional interfacing with living tissues. The device provides high-resolution electrical mapping of dynamic activity. We report precise characterization of electrochemical performance, mechanical properties, bioresorption kinetics, and biocompatibility. While validated in models of cardiac function, this platform establishes a versatile foundation for bioresorbable electrophysiological technologies with applications ranging from postsurgical monitoring of transient conditions to the study and treatment of neurological and neurodegenerative disorders.