Design and Evaluation of Medicated Derma Sticks of Azadirachta indica For Antimicrobial Activity

Topical skin infections commonly occur in person in worldwide level. Plants reported to possess activity or used in traditional systems of medicine for prevention and treatment of skin disorders. Hence, present study was aimed to design and evaluate medicated sticks of Azadirachta indica extract which is very well known for the antibacterial and antifungal activity. The petroleum ether and ethanol (70%) extracts were prepared. Medicated derma sticks of Azadirachta indica extract were prepared by heating and congealing and evaluated for thickness, length and weight. The medicated derma sticks of Azadirachta indica were screened for antimicrobial activity against S. aureus, E. coli and C. albicans, and further stability studies was performed. The prepared medicated derma sticks of Azadirachta indica obtained were of uniform length, thickness and weight respectively. The zones of inhibition of medicated derma sticks of Azadirachta indica against all the microorganisms were nearer to pure drugs. The stability study of medicated derma sticks of Azadirachta indica exhibited that the formulations were safe to use in tropical application.