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Naja haje haje (Egyptian cobra) Venom
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Three toxins (CM‐2, CM‐11 and CM‐12) were purified from Naja haje haje (Egyptian cobra) venom. Whereas toxin CM‐11 contains 65 amino acid residues and five intrachain disulphide bridges, toxin CM‐2 and CM‐12 comprise, respectively, 61 and 62 residues but both contain four disulphide bridges. The complete primary structures of the three toxins have been established. The sequence and the invariant amino acid residues of CM‐2 resemble those of part of a long neurotoxin, a short neurotoxin and a cytotoxin. The sequence of CM‐11 reveals that it is a homologue of the neurotoxins and to some extent also a cytotoxin. The immunochemical properties and the sequence of CM‐12 suggest that it is related to the cytotoxin group. Further, the sequences of CM‐11 and CM‐12 from Naja haje haje venom show a high degree of homology with those of the corresponding toxins isolated from Naja haje annulifera or Naja melanoleuca venoms.
Title: Naja haje haje (Egyptian cobra) Venom
Description:
Three toxins (CM‐2, CM‐11 and CM‐12) were purified from Naja haje haje (Egyptian cobra) venom.
Whereas toxin CM‐11 contains 65 amino acid residues and five intrachain disulphide bridges, toxin CM‐2 and CM‐12 comprise, respectively, 61 and 62 residues but both contain four disulphide bridges.
The complete primary structures of the three toxins have been established.
The sequence and the invariant amino acid residues of CM‐2 resemble those of part of a long neurotoxin, a short neurotoxin and a cytotoxin.
The sequence of CM‐11 reveals that it is a homologue of the neurotoxins and to some extent also a cytotoxin.
The immunochemical properties and the sequence of CM‐12 suggest that it is related to the cytotoxin group.
Further, the sequences of CM‐11 and CM‐12 from Naja haje haje venom show a high degree of homology with those of the corresponding toxins isolated from Naja haje annulifera or Naja melanoleuca venoms.
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