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A Total Synthesis of (+)-Mitragynine
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Here, we disclose a concise total synthesis of (+)-mitragynine, which is the enantiomer of one of the analgesic components of the
Mitragyna speciosa
(kratom) plant. The synthesis proceeds in a linear sequence of seven steps from commercial starting materials and constitutes the shortest preparation of (+)-mitragynine to date. An interesting oxidative cyclization contributes to the convergency of the synthesis.
American Chemical Society (ACS)
Title: A Total Synthesis of (+)-Mitragynine
Description:
Here, we disclose a concise total synthesis of (+)-mitragynine, which is the enantiomer of one of the analgesic components of the
Mitragyna speciosa
(kratom) plant.
The synthesis proceeds in a linear sequence of seven steps from commercial starting materials and constitutes the shortest preparation of (+)-mitragynine to date.
An interesting oxidative cyclization contributes to the convergency of the synthesis.
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