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UROCANIC ACID AND IMMUNOSUPPRESSION
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Abstract—Urocanic acid, a molecule found at high concentration in the stratum corneum, acts as a photoreceptor for UV‐light, isomerizing from the naturally occurring trans‐lorm to the cis‐form. It has been proposed that cis‐urocanic acid may mediate the transient alteration in immune surveillance resulting in immunosuppression induced after UV‐irradiation, by interacting with immune cells locally and/or systemically to generate T cells with suppressor function. The evidence to support this hypothesis is summarized, and possible interactions of urocanic acid with immune cells and their outcome are discussed.
Title: UROCANIC ACID AND IMMUNOSUPPRESSION
Description:
Abstract—Urocanic acid, a molecule found at high concentration in the stratum corneum, acts as a photoreceptor for UV‐light, isomerizing from the naturally occurring trans‐lorm to the cis‐form.
It has been proposed that cis‐urocanic acid may mediate the transient alteration in immune surveillance resulting in immunosuppression induced after UV‐irradiation, by interacting with immune cells locally and/or systemically to generate T cells with suppressor function.
The evidence to support this hypothesis is summarized, and possible interactions of urocanic acid with immune cells and their outcome are discussed.
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