EFFECT OF PINEAPPLE ON GOITER SIZE AND TSH LEVEL

BACKGROUND: Endemic goiter is a major worldwide problem and is a preventable disease. Morethan 12% of world population is affected. Ananas Comosus is considered to be a good source of iodineand vitamin c, which reduce the size of goiter.OBJECTIVE: The study objectives were, l.To measure the goiter size reduction between study andcontrol groups at 4, 8, and ten weeks of intervention 2.Suppression of TSH level up to 25% from baseline.MATERIALS AND METHODS: The study design was Randomized control Trial and SimpleRandom sampling technique was applied. The Sample Size was 7o; study group 35, control group 35.Dose Standardization was done by P.C.S.I.R laboratories complex Lahore. Exclusion Criteria.Subjects suffering from bleeding disorder, liver disease and thyrotoxicosis. History of thyroid surgery,solitary nodular goiter with history of pain and regional lymphadenopathy. Diabetes mellitis, History ofuse of iodized salt, contracting marriage. Goitrogenic food/marine foods intake, change in bowel habitsRESULTS: Subjects suffering from endemic goiter were selected from teaching hospital D.G Khan.Goiter size measurement and TSH estimation was done at 0, 4, 8 and 10 weeks of study. Goiter sizereduction from baseline 4.41±0.86cm to 2.00±1.02 after eight week of intervation was highly significantamong study group P<0.000, and TSH suppresses from baseline 2.63±0.95 to 0.94±0.84 after eight weekP< 0.000. While changes in control group were non significant.CONCLUSION: Ananas Comosus is good alternator remely for endemic goiter patients and a valuablegoiter shrinkage agent.KEY WORDS: PCSIR, Goiter, Ananas Comosus, TSH