Platelet‐Rich Plasma Versus Hyaluronic Acid and Vitamin C With Microneedling in the Treatment of Atrophic Acne Scars: A Comparative Study

ABSTRACT Background and Aim Acne is a chronic inflammatory disease of the pilosebaceous units. Inflammatory acne may result in various kinds of scars, which can have a substantial influence on a patient's social and relationship life. The treatment of acne scars is challenging. To achieve optimal cosmetic results, a multimodal approach is required for scar treatment. The study evaluated the effectiveness and safety of microneedling with non‐crosslinked hyaluronic acid and vitamin C versus platelet‐rich plasma with microneedling for treatment of atrophic acne scars. Methods This study included 34 patients (17–43 years) with atrophic acne scars. Dermapen was applied bilaterally, with platelet‐rich plasma on the right side and non‐crosslinked hyaluronic acid plus vitamin C on the left, over four sessions at three‐week intervals. Results According to Goodman and Baron's qualitative acne scar grading system, both sides showed a significant improvement after treatment ( p  = 0.005, p  < 0.0001 for each group). However, the response was significantly higher on the left side (vitamin C and hyaluronic acid) compared to the right side (PRP). Conclusions We conclude that Dermapen with PRP or hyaluronic acid plus vitamin C improved acne scars, with better results for hyaluronic acid and vitamin C.