Transcatheter Arterial Chemo Infusion (TACI) for Buccal Squamous Cell Carcinoma: A Case Report

Abstract: Buccal squamous cell carcinoma (BSCC) is a rare and aggressive malignancy of the oral cavity. Traditional treatment modalities include surgery, radiotherapy, and chemotherapy. Transcatheter arterial chemo infusion (TACI) is a minimally invasive procedure that delivers chemotherapeutic agents directly to the tumor site, potentially improving local control and reducing systemic toxicity. We reported an 84-year-old male presented with one-year history of a progressively enlarging mass and ulceration on the left cheek, accompanied by pain and bleeding. A previous biopsy and excision in 2023 were followed by tumor recurrence three months prior to this admission. Notable history included extensive sun exposure without protection. Physical examination revealed a 12x8 cm friable mass with necrotic tissue. Histopathology confirmed squamous cell carcinoma. The patient underwent TACI with docetaxel, cisplatin, and 5-FU, resulting in significant tumor reduction and symptomatic improvement. Follow-up imaging and histopathological evaluation confirmed a positive response to the treatment. The patient experienced minimal side effects and maintained a good quality of life. In conclusion, TACI presents a promising alternative for the management of BSCC, particularly in patients who are not suitable candidates for surgery. This case highlights the potential of TACI as an effective and minimally invasive treatment option for BSCC, warranting further investigation in larger clinical trials. Keywords: buccal squamous cell carcinoma; transcatheter arterial chemo infusion