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Lumican, a small leucine‐rich proteoglycan
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Abstract
Lumican belongs to the family of small leucine‐rich repeat proteoglycans. Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of lumican has been correlated to the growth and metastasis of various malignancies; however, its exact role in tumorogenesis remains elusive. This review focuses upon the role of lumican in cell biology, providing insights into molecular mechanisms that lumican likely utilizes to control processes relevant to tumorogenesis. © 2008 IUBMB IUBMB Life, 60(12): 818–823, 2008
Title: Lumican, a small leucine‐rich proteoglycan
Description:
Abstract
Lumican belongs to the family of small leucine‐rich repeat proteoglycans.
Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation.
The expression of lumican has been correlated to the growth and metastasis of various malignancies; however, its exact role in tumorogenesis remains elusive.
This review focuses upon the role of lumican in cell biology, providing insights into molecular mechanisms that lumican likely utilizes to control processes relevant to tumorogenesis.
© 2008 IUBMB IUBMB Life, 60(12): 818–823, 2008.
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The Role of Lumican in Ocular Disease
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