The QuEChERSER Mega-Method

Introduced in 2003, the “quick, easy, cheap, effective, rugged, and safe” (QuEChERS) sample preparation approach has been widely adopted in many applications, particularly in chemical residue analysis of foods. Prior to QuEChERS, sample preparation generally entailed several time-consuming, labor-intensive, and reagent-excessive steps, but the commercialization at the time of powerful, cost-effective, benchtop gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–tandem MS (LC–MS/MS) instruments enabled the implementation of the QuEChERS procedure. Despite analytical technologies continuing to improve over the last two decades, many laboratories are still using QuEChERS protocols developed for outdated instrumentation. Recently, QuEChERS has been updated into QuEChERSER (with “efficient and robust” being added to the portmanteau) to better take advantage of the features provided by modern sample preparation and analytical techniques. Most notably, QuEChERSER is a “mega-method” that covers a broader scope of polar and nonpolar analytes in diverse sample types. In this article, the new QuEChERSER approach and its advantages over QuEChERS are explained.