Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The α‐helical conformation of the undecapeptide boc‐l‐Ala‐[Aib‐Ala]2‐Glu(OBzl)‐Ala‐[Aib‐Ala]2‐OMe: Synthesis, X‐Ray crystal structure, and conformation in solution
View through CrossRef
AbstractAs models of the helical N‐terminal part of alamethicin the undecapeptides Boc‐L‐Ala‐[Aib‐Ala]2‐Glu(OBzl)‐Ala‐[Aib‐Ala]2‐OMe (1) and Boc‐L‐Ala‐[Aib‐Ala]2‐Gly‐Ala‐[Aib‐Ala]2‐OMe (2) were synthesized. 1 was examined by X‐ray crystallography using direct methods for solution of the phase problem. The unit cell (P21) contains two antiparallel α‐helices with nine residues being part of the helix. Continuing chains of head‐to‐tail linked α‐helices are arranged in the crystal lattice. CD and 13C NMR spectra revealed a pronounced stabilizing effect of the α‐aminoisobutyric acid residues for the α‐helical conformation in solution.
Title: The α‐helical conformation of the undecapeptide boc‐l‐Ala‐[Aib‐Ala]2‐Glu(OBzl)‐Ala‐[Aib‐Ala]2‐OMe: Synthesis, X‐Ray crystal structure, and conformation in solution
Description:
AbstractAs models of the helical N‐terminal part of alamethicin the undecapeptides Boc‐L‐Ala‐[Aib‐Ala]2‐Glu(OBzl)‐Ala‐[Aib‐Ala]2‐OMe (1) and Boc‐L‐Ala‐[Aib‐Ala]2‐Gly‐Ala‐[Aib‐Ala]2‐OMe (2) were synthesized.
1 was examined by X‐ray crystallography using direct methods for solution of the phase problem.
The unit cell (P21) contains two antiparallel α‐helices with nine residues being part of the helix.
Continuing chains of head‐to‐tail linked α‐helices are arranged in the crystal lattice.
CD and 13C NMR spectra revealed a pronounced stabilizing effect of the α‐aminoisobutyric acid residues for the α‐helical conformation in solution.
Related Results
Crystal structure of the α‐helical undecapeptide Boc‐L‐Ala‐Aib‐Ala‐Aib‐Ala‐Glu(OBzl)‐Ala‐Aib‐Ala‐Aib‐Ala‐OMe
Crystal structure of the α‐helical undecapeptide Boc‐L‐Ala‐Aib‐Ala‐Aib‐Ala‐Glu(OBzl)‐Ala‐Aib‐Ala‐Aib‐Ala‐OMe
AbstractThe x‐ray structure of Boc‐L‐Ala‐Aib‐Ala‐Aib‐Ala‐Glu(OBzl)‐Ala‐Aib‐Ala‐Aib‐Ala‐OMe(I) represents the first α‐helix determined by direct methods. This undecapeptide is a mod...
Sintesis Konjugat Kurkumin Tirosin dan Valin sebagai Kandidat Antibakteri Escherichia coli
Sintesis Konjugat Kurkumin Tirosin dan Valin sebagai Kandidat Antibakteri Escherichia coli
Abstract. It has been proven that the potential of curcumin as an antibacterial and immunomodulatory agent has extensively shown broad-spectrum antibacterial activity against Gram-...
Alpha-helix and mixed 3(10)/alpha-helix in cocrystallized conformers of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe.
Alpha-helix and mixed 3(10)/alpha-helix in cocrystallized conformers of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe.
Two molecules of Boc-Aib-Val-Aib-Aib-Val-Val-Val-Aib-Val-Aib-OMe (where Boc is t-butoxycarbonyl and Aib is alpha-aminoisobutyryl) cocrystallize in a triclinic cell with different h...
Stereochemistry of α‐aminoisobutyric acid peptides in solution: Conformations of decapeptides with a central triplet of contiguous L‐amino acids
Stereochemistry of α‐aminoisobutyric acid peptides in solution: Conformations of decapeptides with a central triplet of contiguous L‐amino acids
AbstractThe decapeptides Boc‐Aib‐L‐Val‐Aib‐Aib‐(L‐Val)3‐Aib‐L‐Val‐Aib‐OMe and Boc‐Aib‐L‐Leu‐Aib‐Aib‐(L‐Leu)3‐Aib‐L‐Leu‐Aib‐OMe have been studied in CDCl3 and (CD3)2SO solutions by ...
Sequences of Metanicins, 20‐Residue Peptaibols from the Ascomycetous Fungus CBS 597.80
Sequences of Metanicins, 20‐Residue Peptaibols from the Ascomycetous Fungus CBS 597.80
AbstractFour linear 20‐residue peptaibols, named metanicins (MTCs) A–D, were isolated from submerged cultures of the ascomycetous fungus CBS 597.80. Structure elucidation was perfo...
Glutamate transport asymmetry in renal glutamine metabolism
Glutamate transport asymmetry in renal glutamine metabolism
d-Glutamate (Glu) was previously shown to block l-Glu uptake and accelerate glutaminase flux in cultured kidney cells [Welbourne, T. C., and D. Chevalier. Am. J. Physiol. 272 ( End...
Helix aggregation in peptide crystals: Occurrence of either all parallel or antiparallel packing motifs for α‐helices in polymorphs of Boc‐Aib‐Ala‐Leu‐Ala‐Leu‐Aib‐Leu‐Ala‐Leu‐Aib‐OMe
Helix aggregation in peptide crystals: Occurrence of either all parallel or antiparallel packing motifs for α‐helices in polymorphs of Boc‐Aib‐Ala‐Leu‐Ala‐Leu‐Aib‐Leu‐Ala‐Leu‐Aib‐OMe
AbstractThree crystalline polymorphs of the helical decapeptide, Boc‐Aib‐Ala‐Leu‐Ala‐Leu‐Aib‐Leu‐Ala‐Leu‐Aib‐OMe, have been obtained. Antiparallel helix aggregation is observed in ...
ChemInform Abstract: THE α‐HELICAL CONFORMATION OF THE UNDECAPEPTIDE BOC‐L‐ALA‐(AIB‐ALA)2‐GLU(OBZL)‐ALA‐(AIB‐ALA)2‐OME: SYNTHESIS, X‐RAY CRYSTAL STRUCTURE, AND CONFORMATION IN SOLUTION
ChemInform Abstract: THE α‐HELICAL CONFORMATION OF THE UNDECAPEPTIDE BOC‐L‐ALA‐(AIB‐ALA)2‐GLU(OBZL)‐ALA‐(AIB‐ALA)2‐OME: SYNTHESIS, X‐RAY CRYSTAL STRUCTURE, AND CONFORMATION IN SOLUTION
AbstractAls Modelle des N‐terminalen Teils von Alamethicin wurden die Undecapeptide (Ia) und (Ib) nach konventionellen Methoden [Kondensation schrittweise aufgebauter Fragmente (5+...